Anti-CCR2/ CC-CKR-2/ CCR-2A monoclonal antibody

Anti-CCR2/ CC-CKR-2/ CCR-2A antibody for FACS & in-vivo assay

Target products collectionGo to CCR2/CCR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T89988-Ab-1/ GM-Tg-hg-T89988-Ab-2Anti-Human CCR2 monoclonal antibodyHuman
GM-Tg-rg-T89988-Ab-1/ GM-Tg-rg-T89988-Ab-2Anti-Rat CCR2 monoclonal antibodyRat
GM-Tg-mg-T89988-Ab-1/ GM-Tg-mg-T89988-Ab-2Anti-Mouse CCR2 monoclonal antibodyMouse
GM-Tg-cynog-T89988-Ab-1/ GM-Tg-cynog-T89988-Ab-2Anti-Cynomolgus/ Rhesus macaque CCR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T89988-Ab-1/ GM-Tg-felg-T89988-Ab-2Anti-Feline CCR2 monoclonal antibodyFeline
GM-Tg-cang-T89988-Ab-1/ GM-Tg-cang-T89988-Ab-2Anti-Canine CCR2 monoclonal antibodyCanine
GM-Tg-bovg-T89988-Ab-1/ GM-Tg-bovg-T89988-Ab-2Anti-Bovine CCR2 monoclonal antibodyBovine
GM-Tg-equg-T89988-Ab-1/ GM-Tg-equg-T89988-Ab-2Anti-Equine CCR2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T89988-Ab-1/ GM-Tg-hg-T89988-Ab-2; GM-Tg-rg-T89988-Ab-1/ GM-Tg-rg-T89988-Ab-2;
GM-Tg-mg-T89988-Ab-1/ GM-Tg-mg-T89988-Ab-2; GM-Tg-cynog-T89988-Ab-1/ GM-Tg-cynog-T89988-Ab-2;
GM-Tg-felg-T89988-Ab-1/ GM-Tg-felg-T89988-Ab-2; GM-Tg-cang-T89988-Ab-1/ GM-Tg-cang-T89988-Ab-2;
GM-Tg-bovg-T89988-Ab-1/ GM-Tg-bovg-T89988-Ab-2; GM-Tg-equg-T89988-Ab-1/ GM-Tg-equg-T89988-Ab-2
Products NameAnti-CCR2 monoclonal antibody
Formatmab
Target NameCCR2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CCR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-447Pre-Made Plozalizumab biosimilar, Whole mAb, Anti-CCR2 Antibody: Anti-CKR2/CD192/CKR2A/CKR2B/CMKBR2/MCP-1-R/CC-CKR-2 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CCR2/ CC-CKR-2/ CCR-2A VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T89988-Ag-1chemokine (C-C motif) receptor 2 (CCR2) protein
    ORF Viral VectorvGMLV000474human CCR2 Lentivirus particle
    ORF Viral VectorpGMLV000397human CCR2 Lentivirus plasmid
    ORF Viral VectorpGMLV000474human CCR2 Lentivirus plasmid
    ORF Viral VectorvGMLV000397human CCR2 Lentivirus particle
    ORF Viral VectorpGMLPm002788mouse Ccr2 Lentivirus plasmid
    ORF Viral VectorvGMLPm002788mouse Ccr2 Lentivirus particle


    Target information

    Target IDGM-T89988
    Target NameCCR2
    Gene ID729230,12772,574098,539002
    Gene Symbol and SynonymsCC-CKR-2,CCR-2,CCR2,CCR2A,CCR2B,CD192,CKR2,CKR2A,CKR2B,CMKBR2,MCP-1-R,mJe-r
    Uniprot AccessionP41597,O18793
    Uniprot Entry NameCCR2_HUMAN,CCR2_MACMU
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000121807
    Target ClassificationCheckpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA)

    The target: CCR2, gene name: CCR2, also named as CC-CKR-2, CCR-2A, CCR2B, CD192, CKR2, CKR2A, CKR2B, CMKBR2, MCP-1-R, CCR2. The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.