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Anti-TNR1A/ TNF-R1/ TNFRSF1A monoclonal antibody
Anti-TNR1A/ TNF-R1/ TNFRSF1A antibody for FACS & in-vivo assay
Go to TNF-R1/TNFRSF1A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T86552-Ab-1/ GM-Tg-hg-T86552-Ab-2 | Anti-Human TNF-R1/TNFRSF1A monoclonal antibody | Human |
| GM-Tg-rg-T86552-Ab-1/ GM-Tg-rg-T86552-Ab-2 | Anti-Rat TNF-R1/TNFRSF1A monoclonal antibody | Rat |
| GM-Tg-mg-T86552-Ab-1/ GM-Tg-mg-T86552-Ab-2 | Anti-Mouse TNF-R1/TNFRSF1A monoclonal antibody | Mouse |
| GM-Tg-cynog-T86552-Ab-1/ GM-Tg-cynog-T86552-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNF-R1/TNFRSF1A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T86552-Ab-1/ GM-Tg-felg-T86552-Ab-2 | Anti-Feline TNF-R1/TNFRSF1A monoclonal antibody | Feline |
| GM-Tg-cang-T86552-Ab-1/ GM-Tg-cang-T86552-Ab-2 | Anti-Canine TNF-R1/TNFRSF1A monoclonal antibody | Canine |
| GM-Tg-bovg-T86552-Ab-1/ GM-Tg-bovg-T86552-Ab-2 | Anti-Bovine TNF-R1/TNFRSF1A monoclonal antibody | Bovine |
| GM-Tg-equg-T86552-Ab-1/ GM-Tg-equg-T86552-Ab-2 | Anti-Equine TNF-R1/TNFRSF1A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T86552-Ab-1/ GM-Tg-hg-T86552-Ab-2; GM-Tg-rg-T86552-Ab-1/ GM-Tg-rg-T86552-Ab-2; GM-Tg-mg-T86552-Ab-1/ GM-Tg-mg-T86552-Ab-2; GM-Tg-cynog-T86552-Ab-1/ GM-Tg-cynog-T86552-Ab-2; GM-Tg-felg-T86552-Ab-1/ GM-Tg-felg-T86552-Ab-2; GM-Tg-cang-T86552-Ab-1/ GM-Tg-cang-T86552-Ab-2; GM-Tg-bovg-T86552-Ab-1/ GM-Tg-bovg-T86552-Ab-2; GM-Tg-equg-T86552-Ab-1/ GM-Tg-equg-T86552-Ab-2 |
| Products Name | Anti-TNF-R1/TNFRSF1A monoclonal antibody |
| Format | mab |
| Target Name | TNF-R1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNF-R1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-1007 | Pre-Made Tanfanercept biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting TNF-α receptor |
| Target Antigen | Products Developing | Multi-species TNR1A/ TNF-R1/ TNFRSF1A VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T86552-Ag-1 | Tumor necrosis factor receptor superfamily, member 1A (TNFRSF1A) protein |
| ORF Viral Vector | vGMAD000422 | human TNFRSF1A Adenovirus particle |
| ORF Viral Vector | pGMAD000422 | human TNFRSF1A Adenovirus plasmid |
| ORF Viral Vector | pGMLPm005329 | mouse Tnfrsf1a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005329 | mouse Tnfrsf1a Lentivirus particle |
Target information
| Target ID | GM-T86552 |
| Target Name | TNF-R1 |
| Gene ID | 7132,21937,25625,722033,403634,493957,282527,100059548 |
| Gene Symbol and Synonyms | CD120a,FPF,p55,p55-R,p60,TBP1,TNF-alphaR1,TNF-R,TNF-R-I,TNF-R1,TNF-R55,TNFalpha-R1,TNFAR,TNFR I,TNFR-1,Tnfr-2,TNFR1,TNFR55,TNFR60,TNFRI,TNFRp55,TNFRSF1A |
| Uniprot Accession | P19438,P22934,O19131 |
| Uniprot Entry Name | TNR1A_HUMAN,TNR1A_RAT,TNR1A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Breast Cancer, tumor necrosis factor (TNF) receptor-associated periodic syndrome, Rheumatoid vasculitis with rheumatoid arthritis |
| Gene Ensembl | ENSG00000067182 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TNF-R1, gene name: TNFRSF1A, also named as CD120a, FPF, TBP1, TNF-R, TNF-R-I, TNF-R55, TNFAR, TNFR1, TNFR55, TNFR60, p55, p55-R, p60. This gene encodes a member of the TNF receptor superfamily of proteins. The encoded receptor is found in membrane-bound and soluble forms that interact with membrane-bound and soluble forms, respectively, of its ligand, tumor necrosis factor alpha. Binding of membrane-bound tumor necrosis factor alpha to the membrane-bound receptor induces receptor trimerization and activation, which plays a role in cell survival, apoptosis, and inflammation. Proteolytic processing of the encoded receptor results in release of the soluble form of the receptor, which can interact with free tumor necrosis factor alpha to inhibit inflammation. Mutations in this gene underlie tumor necrosis factor receptor-associated periodic syndrome (TRAPS), characterized by fever, abdominal pain and other features. Mutations in this gene may also be associated with multiple sclerosis in human patients. [provided by RefSeq, Sep 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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