Anti-AGTR1/ AG2SB/ AT1 monoclonal antibody

Anti-AGTR1/ AG2SB/ AT1 antibody for FACS & in-vivo assay

Target products collectionGo to AGTR1/AGTR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T74456-Ab-1/ GM-Tg-hg-T74456-Ab-2Anti-Human AGTR1 monoclonal antibodyHuman
GM-Tg-rg-T74456-Ab-1/ GM-Tg-rg-T74456-Ab-2Anti-Rat AGTR1 monoclonal antibodyRat
GM-Tg-mg-T74456-Ab-1/ GM-Tg-mg-T74456-Ab-2Anti-Mouse AGTR1 monoclonal antibodyMouse
GM-Tg-cynog-T74456-Ab-1/ GM-Tg-cynog-T74456-Ab-2Anti-Cynomolgus/ Rhesus macaque AGTR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T74456-Ab-1/ GM-Tg-felg-T74456-Ab-2Anti-Feline AGTR1 monoclonal antibodyFeline
GM-Tg-cang-T74456-Ab-1/ GM-Tg-cang-T74456-Ab-2Anti-Canine AGTR1 monoclonal antibodyCanine
GM-Tg-bovg-T74456-Ab-1/ GM-Tg-bovg-T74456-Ab-2Anti-Bovine AGTR1 monoclonal antibodyBovine
GM-Tg-equg-T74456-Ab-1/ GM-Tg-equg-T74456-Ab-2Anti-Equine AGTR1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T74456-Ab-1/ GM-Tg-hg-T74456-Ab-2; GM-Tg-rg-T74456-Ab-1/ GM-Tg-rg-T74456-Ab-2;
GM-Tg-mg-T74456-Ab-1/ GM-Tg-mg-T74456-Ab-2; GM-Tg-cynog-T74456-Ab-1/ GM-Tg-cynog-T74456-Ab-2;
GM-Tg-felg-T74456-Ab-1/ GM-Tg-felg-T74456-Ab-2; GM-Tg-cang-T74456-Ab-1/ GM-Tg-cang-T74456-Ab-2;
GM-Tg-bovg-T74456-Ab-1/ GM-Tg-bovg-T74456-Ab-2; GM-Tg-equg-T74456-Ab-1/ GM-Tg-equg-T74456-Ab-2
Products NameAnti-AGTR1 monoclonal antibody
Formatmab
Target NameAGTR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AGTR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AGTR1/ AG2SB/ AT1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000160human AGTR1 Lentivirus plasmid
    ORF Viral VectorvGMLV000160human AGTR1 Lentivirus particle
    ORF Viral VectorpGMAD000019human AGTR1 Adenovirus plasmid
    ORF Viral VectorvGMAD000019human AGTR1 Adenovirus particle
    ORF Viral VectorpGMLPm001804mouse Agtr1a Lentivirus plasmid
    ORF Viral VectorvGMLPm001804mouse Agtr1a Lentivirus particle


    Target information

    Target IDGM-T74456
    Target NameAGTR1
    Gene ID185,11608,81638,712773,403836,101082936,281607,100059005
    Gene Symbol and SynonymsAG2S,Agtr-1b,AGTR1,AGTR1B,Angtr-1b,AT1,AT1AR,AT1B,AT1BR,AT1R,AT2R1,AT2R1B,AT3,AT1R,ATR1,HAT1R
    Uniprot AccessionP30556,P29089,P43240,P25104
    Uniprot Entry NameAGTR1_HUMAN,AGTRB_RAT,AGTR1_CANLF,AGTR1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000144891
    Target ClassificationGPCR

    The target: AGTR1, gene name: AGTR1, also named as AG2SB, AT1, AT1AR, AT1B, AT1BR, AT1R, AT2R1, HAT1R, AGTR1. Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.