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Anti-NGAL/ LCN2/ 24p3 functional antibody
Anti-NGAL/ LCN2/ 24p3 functional antibody for cell culture, ELISA & in-vivo assay
Go to LCN2/LCN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T72010-Ab-1/ GM-Tg-hg-T72010-Ab-2 | Anti-Human LCN2 monoclonal antibody | Human |
| GM-Tg-rg-T72010-Ab-1/ GM-Tg-rg-T72010-Ab-2 | Anti-Rat LCN2 monoclonal antibody | Rat |
| GM-Tg-mg-T72010-Ab-1/ GM-Tg-mg-T72010-Ab-2 | Anti-Mouse LCN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T72010-Ab-1/ GM-Tg-cynog-T72010-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LCN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T72010-Ab-1/ GM-Tg-felg-T72010-Ab-2 | Anti-Feline LCN2 monoclonal antibody | Feline |
| GM-Tg-cang-T72010-Ab-1/ GM-Tg-cang-T72010-Ab-2 | Anti-Canine LCN2 monoclonal antibody | Canine |
| GM-Tg-bovg-T72010-Ab-1/ GM-Tg-bovg-T72010-Ab-2 | Anti-Bovine LCN2 monoclonal antibody | Bovine |
| GM-Tg-equg-T72010-Ab-1/ GM-Tg-equg-T72010-Ab-2 | Anti-Equine LCN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T72010-Ab-1/ GM-Tg-hg-T72010-Ab-2; GM-Tg-rg-T72010-Ab-1/ GM-Tg-rg-T72010-Ab-2; GM-Tg-mg-T72010-Ab-1/ GM-Tg-mg-T72010-Ab-2; GM-Tg-cynog-T72010-Ab-1/ GM-Tg-cynog-T72010-Ab-2; GM-Tg-felg-T72010-Ab-1/ GM-Tg-felg-T72010-Ab-2; GM-Tg-cang-T72010-Ab-1/ GM-Tg-cang-T72010-Ab-2; GM-Tg-bovg-T72010-Ab-1/ GM-Tg-bovg-T72010-Ab-2; GM-Tg-equg-T72010-Ab-1/ GM-Tg-equg-T72010-Ab-2 |
| Products Name | Anti-LCN2 monoclonal antibody |
| Format | mab |
| Target Name | LCN2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LCN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T72010-Ag-1 | Recombinant multi-species NGAL/ LCN2/ 24p3 protein |
| ORF Viral Vector | vGMLP002859 | human LCN2 Lentivirus particle |
| ORF Viral Vector | pGMLP002859 | human LCN2 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000092 | rat Lcn2 AAV plasmid |
| ORF Viral Vector | pGMLPm001038 | mouse Lcn2 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000092 | rat Lcn2 AAV particle |
| ORF Viral Vector | vGMLPm001038 | mouse Lcn2 Lentivirus particle |
Target information
| Target ID | GM-T72010 |
| Target Name | LCN2 |
| Gene ID | 3934,16819,170496,697208,526639,100070310 |
| Gene Symbol and Synonyms | 24p3,LCN2,MSFI,NGAL,NRL,p25,Sip24 |
| Uniprot Accession | P80188,P30152 |
| Uniprot Entry Name | NGAL_HUMAN,NGAL_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Prostate Cancer, Complications of kidney transplant, Congenital hydronephrosis, Congenital occlusion of ureteropelvic junction, Contact with and (suspected) exposure to hazardous aromatic compounds, Contrast - Induced Nephropathy, Delayed Graft Function, Dent disease, Diabetic Nephropathy, HIV-Associated Nephropathy, Hydronephrosis, Hypertension, Impaired renal function disease, Injury to Kidney, Intraoperative Renal Injury, Kidney transplant rejection, Lupus Glomerulonephritis, Neonatal urinary tract infection, Nephrectomy, Nephropathy induced by other drugs, medicaments and biological substances, Nephrotic syndrome, Nephrotic syndrome with diffuse membranous glomerulonephritis, Proteinuria, Renal fibrosis, Renovascular hypertension, Sepsis due to Enterococcus, Systemic inflammatory response syndrome (SIRS) of non-infectious origin with acute organ dysfunction, Systemic lupus erythematosus (SLE), Transplanted Heart Complication, Type 1 diabetes mellitus with diabetic nephropathy, Acute pancreatitis, Asphyxia neonatorum, Autosomal Dominant Polycystic Kidney Disease, Cardiogenic shock, Chronic Kidney Disease, Type 2 diabetes mellitus, Vasculitis, Vesicoureteral reflux |
| Gene Ensembl | ENSG00000148346 |
| Target Classification | N/A |
The target: LCN2, gene name: LCN2, also named as 24p3, MSFI, NGAL, p25. This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin and plays a role in innate immunity by limiting bacterial growth as a result of sequestering iron-containing siderophores. The presence of this protein in blood and urine is an early biomarker of acute kidney injury. This protein is thought to be be involved in multiple cellular processes, including maintenance of skin homeostasis, and suppression of invasiveness and metastasis. Mice lacking this gene are more susceptible to bacterial infection than wild type mice. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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