Anti-DRD2/ D2R/ D2DR monoclonal antibody

Anti-DRD2/ D2R/ D2DR antibody for FACS & in-vivo assay

Target products collectionGo to D2R/DRD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T67162-Ab-1/ GM-Tg-hg-T67162-Ab-2Anti-Human D2R/DRD2 monoclonal antibodyHuman
GM-Tg-rg-T67162-Ab-1/ GM-Tg-rg-T67162-Ab-2Anti-Rat D2R/DRD2 monoclonal antibodyRat
GM-Tg-mg-T67162-Ab-1/ GM-Tg-mg-T67162-Ab-2Anti-Mouse D2R/DRD2 monoclonal antibodyMouse
GM-Tg-cynog-T67162-Ab-1/ GM-Tg-cynog-T67162-Ab-2Anti-Cynomolgus/ Rhesus macaque D2R/DRD2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T67162-Ab-1/ GM-Tg-felg-T67162-Ab-2Anti-Feline D2R/DRD2 monoclonal antibodyFeline
GM-Tg-cang-T67162-Ab-1/ GM-Tg-cang-T67162-Ab-2Anti-Canine D2R/DRD2 monoclonal antibodyCanine
GM-Tg-bovg-T67162-Ab-1/ GM-Tg-bovg-T67162-Ab-2Anti-Bovine D2R/DRD2 monoclonal antibodyBovine
GM-Tg-equg-T67162-Ab-1/ GM-Tg-equg-T67162-Ab-2Anti-Equine D2R/DRD2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T67162-Ab-1/ GM-Tg-hg-T67162-Ab-2; GM-Tg-rg-T67162-Ab-1/ GM-Tg-rg-T67162-Ab-2;
GM-Tg-mg-T67162-Ab-1/ GM-Tg-mg-T67162-Ab-2; GM-Tg-cynog-T67162-Ab-1/ GM-Tg-cynog-T67162-Ab-2;
GM-Tg-felg-T67162-Ab-1/ GM-Tg-felg-T67162-Ab-2; GM-Tg-cang-T67162-Ab-1/ GM-Tg-cang-T67162-Ab-2;
GM-Tg-bovg-T67162-Ab-1/ GM-Tg-bovg-T67162-Ab-2; GM-Tg-equg-T67162-Ab-1/ GM-Tg-equg-T67162-Ab-2
Products NameAnti-D2R/DRD2 monoclonal antibody
Formatmab
Target NameD2R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-D2R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species DRD2/ D2R/ D2DR VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMAP000308Human DRD2 Adenovirus particle
    ORF Viral VectorvGMLV000444human DRD2 Lentivirus particle
    ORF Viral VectorpGMLV000466human DRD2 Lentivirus plasmid
    ORF Viral VectorpGMLV000806human DRD2 Lentivirus plasmid
    ORF Viral VectorvGMLV000806human DRD2 Lentivirus particle
    ORF Viral VectorpGMAP000308Human DRD2 Adenovirus plasmid
    ORF Viral VectorpGMLV000444human DRD2 Lentivirus plasmid
    ORF Viral VectorvGMLV000466human DRD2 Lentivirus particle
    ORF Viral VectorpGMLPm005196mouse Drd2 Lentivirus plasmid
    ORF Viral VectorvGMLPm005196mouse Drd2 Lentivirus particle


    Target information

    Target IDGM-T67162
    Target NameD2R
    Gene ID1813,13489,24318,694181,403701,101096838,281126,100062195
    Gene Symbol and SynonymsD2DR,D2R,Drd-2,DRD2
    Uniprot AccessionP14416,P61169,Q9GJU1,P20288
    Uniprot Entry NameDRD2_HUMAN,DRD2_RAT,DRD2_CANLF,DRD2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000149295
    Target ClassificationGPCR, Tumor-associated antigen (TAA)

    The target: D2R, gene name: DRD2, also named as D2DR, D2R. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.