Anti-IBP2/ IGFBP2/ IGF-BP53 functional antibody

Anti-IBP2/ IGFBP2/ IGF-BP53 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IGFBP2/IGFBP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T64268-Ab-1/ GM-Tg-hg-T64268-Ab-2Anti-Human IGFBP2 monoclonal antibodyHuman
GM-Tg-rg-T64268-Ab-1/ GM-Tg-rg-T64268-Ab-2Anti-Rat IGFBP2 monoclonal antibodyRat
GM-Tg-mg-T64268-Ab-1/ GM-Tg-mg-T64268-Ab-2Anti-Mouse IGFBP2 monoclonal antibodyMouse
GM-Tg-cynog-T64268-Ab-1/ GM-Tg-cynog-T64268-Ab-2Anti-Cynomolgus/ Rhesus macaque IGFBP2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T64268-Ab-1/ GM-Tg-felg-T64268-Ab-2Anti-Feline IGFBP2 monoclonal antibodyFeline
GM-Tg-cang-T64268-Ab-1/ GM-Tg-cang-T64268-Ab-2Anti-Canine IGFBP2 monoclonal antibodyCanine
GM-Tg-bovg-T64268-Ab-1/ GM-Tg-bovg-T64268-Ab-2Anti-Bovine IGFBP2 monoclonal antibodyBovine
GM-Tg-equg-T64268-Ab-1/ GM-Tg-equg-T64268-Ab-2Anti-Equine IGFBP2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T64268-Ab-1/ GM-Tg-hg-T64268-Ab-2; GM-Tg-rg-T64268-Ab-1/ GM-Tg-rg-T64268-Ab-2;
GM-Tg-mg-T64268-Ab-1/ GM-Tg-mg-T64268-Ab-2; GM-Tg-cynog-T64268-Ab-1/ GM-Tg-cynog-T64268-Ab-2;
GM-Tg-felg-T64268-Ab-1/ GM-Tg-felg-T64268-Ab-2; GM-Tg-cang-T64268-Ab-1/ GM-Tg-cang-T64268-Ab-2;
GM-Tg-bovg-T64268-Ab-1/ GM-Tg-bovg-T64268-Ab-2; GM-Tg-equg-T64268-Ab-1/ GM-Tg-equg-T64268-Ab-2
Products NameAnti-IGFBP2 monoclonal antibody
Formatmab
Target NameIGFBP2
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IGFBP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T64268-Ag-1Recombinant multi-species IBP2/ IGFBP2/ IGF-BP53 protein
    CytokineGM-Tg-g-T64268-Ag-1insulin-like growth factor binding protein 2, 36kDa (IGFBP2) protein
    ORF Viral VectorvGMLP004595human IGFBP2 Lentivirus particle
    ORF Viral VectorpGMLP004595human IGFBP2 Lentivirus plasmid
    ORF Viral VectorpGMLPm003848mouse Igfbp2 Lentivirus plasmid
    ORF Viral VectorvGMLPm003848mouse Igfbp2 Lentivirus particle


    Target information

    Target IDGM-T64268
    Target NameIGFBP2
    Gene ID3485,16008,25662,696214,488516,101088426,282260,100034061
    Gene Symbol and SynonymsBRL-BP,IBP-2,IBP2,IGF-BP53,Igfbp-2,IGFBP2,ILGFBPA,mIGFBP-2
    Uniprot AccessionP18065,P12843,P13384
    Uniprot Entry NameIBP2_HUMAN,IBP2_RAT,IBP2_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseOvary Cancer, Dent disease
    Gene EnsemblENSG00000115457
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IGFBP2, gene name: IGFBP2, also named as IBP2, IGF-BP53. The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.