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Anti-RAD51 monoclonal antibody
Pre-made anti-RAD51 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RAD51/RAD51 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T63083-Ab-1/ GM-Tg-hg-T63083-Ab-2 | Anti-Human RAD51 monoclonal antibody | Human |
| GM-Tg-rg-T63083-Ab-1/ GM-Tg-rg-T63083-Ab-2 | Anti-Rat RAD51 monoclonal antibody | Rat |
| GM-Tg-mg-T63083-Ab-1/ GM-Tg-mg-T63083-Ab-2 | Anti-Mouse RAD51 monoclonal antibody | Mouse |
| GM-Tg-cynog-T63083-Ab-1/ GM-Tg-cynog-T63083-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RAD51 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T63083-Ab-1/ GM-Tg-felg-T63083-Ab-2 | Anti-Feline RAD51 monoclonal antibody | Feline |
| GM-Tg-cang-T63083-Ab-1/ GM-Tg-cang-T63083-Ab-2 | Anti-Canine RAD51 monoclonal antibody | Canine |
| GM-Tg-bovg-T63083-Ab-1/ GM-Tg-bovg-T63083-Ab-2 | Anti-Bovine RAD51 monoclonal antibody | Bovine |
| GM-Tg-equg-T63083-Ab-1/ GM-Tg-equg-T63083-Ab-2 | Anti-Equine RAD51 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T63083-Ab-1/ GM-Tg-hg-T63083-Ab-2; GM-Tg-rg-T63083-Ab-1/ GM-Tg-rg-T63083-Ab-2; GM-Tg-mg-T63083-Ab-1/ GM-Tg-mg-T63083-Ab-2; GM-Tg-cynog-T63083-Ab-1/ GM-Tg-cynog-T63083-Ab-2; GM-Tg-felg-T63083-Ab-1/ GM-Tg-felg-T63083-Ab-2; GM-Tg-cang-T63083-Ab-1/ GM-Tg-cang-T63083-Ab-2; GM-Tg-bovg-T63083-Ab-1/ GM-Tg-bovg-T63083-Ab-2; GM-Tg-equg-T63083-Ab-1/ GM-Tg-equg-T63083-Ab-2 |
| Products Name | Anti-RAD51 monoclonal antibody |
| Format | mab |
| Target Name | RAD51 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RAD51 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T63083-Ag-1 | Recombinant multi-species RAD51/ BRCC5/ FANCR protein |
| ORF Viral Vector | vGMLV000274 | human RAD51 Lentivirus particle |
| ORF Viral Vector | pGMLV000274 | human RAD51 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002886 | mouse Rad51 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002886 | mouse Rad51 Lentivirus particle |
Target information
| Target ID | GM-T63083 |
| Target Name | RAD51 |
| Gene ID | 5888,19361,499870,708579,403568,101089015,514749,100071340 |
| Gene Symbol and Synonyms | BRCC5,CRAD51,FANCR,HRAD51,HsRad51,HsT16930,MRMV2,RAD51,RAD51A,RECA,RGD1563603 |
| Uniprot Accession | Q06609,Q8MKI8,Q2KJ94 |
| Uniprot Entry Name | RAD51_HUMAN,RAD51_CANLF,RAD51_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000051180 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: RAD51, gene name: RAD51, also named as BRCC5, FANCR, HRAD51, HsRad51, HsT16930, MRMV2A, RECA, RAD51. The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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