Anti-IGF1/ IGF/ IGF-I functional antibody

Anti-IGF1/ IGF/ IGF-I functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IGF1/IGF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T60930-Ab-1/ GM-Tg-hg-T60930-Ab-2Anti-Human IGF1 monoclonal antibodyHuman
GM-Tg-rg-T60930-Ab-1/ GM-Tg-rg-T60930-Ab-2Anti-Rat IGF1 monoclonal antibodyRat
GM-Tg-mg-T60930-Ab-1/ GM-Tg-mg-T60930-Ab-2Anti-Mouse IGF1 monoclonal antibodyMouse
GM-Tg-cynog-T60930-Ab-1/ GM-Tg-cynog-T60930-Ab-2Anti-Cynomolgus/ Rhesus macaque IGF1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T60930-Ab-1/ GM-Tg-felg-T60930-Ab-2Anti-Feline IGF1 monoclonal antibodyFeline
GM-Tg-cang-T60930-Ab-1/ GM-Tg-cang-T60930-Ab-2Anti-Canine IGF1 monoclonal antibodyCanine
GM-Tg-bovg-T60930-Ab-1/ GM-Tg-bovg-T60930-Ab-2Anti-Bovine IGF1 monoclonal antibodyBovine
GM-Tg-equg-T60930-Ab-1/ GM-Tg-equg-T60930-Ab-2Anti-Equine IGF1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T60930-Ab-1/ GM-Tg-hg-T60930-Ab-2; GM-Tg-rg-T60930-Ab-1/ GM-Tg-rg-T60930-Ab-2;
GM-Tg-mg-T60930-Ab-1/ GM-Tg-mg-T60930-Ab-2; GM-Tg-cynog-T60930-Ab-1/ GM-Tg-cynog-T60930-Ab-2;
GM-Tg-felg-T60930-Ab-1/ GM-Tg-felg-T60930-Ab-2; GM-Tg-cang-T60930-Ab-1/ GM-Tg-cang-T60930-Ab-2;
GM-Tg-bovg-T60930-Ab-1/ GM-Tg-bovg-T60930-Ab-2; GM-Tg-equg-T60930-Ab-1/ GM-Tg-equg-T60930-Ab-2
Products NameAnti-IGF1 monoclonal antibody
Formatmab
Target NameIGF1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IGF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-634Pre-Made Xentuzumab biosimilar, Whole mAb, Anti-IGF1;IGF2 Antibody: Anti-IGF/IGF-I/IGFI/MGF;C11orf43/GRDF/IGF-II/PP9974/SRS3 therapeutic antibody
    BiosimilarGMP-Bios-ab-160Pre-Made Dusigitumab biosimilar, Whole mAb, Anti-IGF1;IGF2 Antibody: Anti-IGF/IGF-I/IGFI/MGF;C11orf43/GRDF/IGF-II/PP9974/SRS3 therapeutic antibody
    Target AntigenGM-Tg-g-T60930-Ag-1Recombinant multi-species IGF1/ IGF/ IGF-I protein
    CytokineGM-Tg-g-T60930-Ag-1insulin-like growth factor 1 (IGF1) protein
    ORF Viral VectorvGMLV000664human IGF-1 Lentivirus particle
    ORF Viral VectorpGMAD000056human IGF1 Adenovirus plasmid
    ORF Viral VectorvGMAD000056human IGF1 Adenovirus particle
    ORF Viral VectorpGMLP003306human IGF1 Lentivirus plasmid
    ORF Viral VectorvGMLP003306human IGF1 Lentivirus particle
    ORF Viral VectorpGMLV000664human IGF-1 Lentivirus plasmid
    ORF Viral VectorpGMLV000522house mouse Igf1 Lentivirus plasmid
    ORF Viral VectorpGMAD000636Norway rat Igf1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000050mouse Igf1 AAV plasmid
    ORF Viral VectorvGMLV000522house mouse Igf1 Lentivirus particle
    ORF Viral VectorvGMAD000636Norway rat Igf1 Adenovirus particle
    ORF Viral VectorvGMAAV000050mouse Igf1 AAV particle


    Target information

    Target IDGM-T60930
    Target NameIGF1
    Gene ID3479,16000,24482,698444,610255,101101237,281239,100034198
    Gene Symbol and SynonymsC730016P09Rik,IGF,Igf-1,IGF-I,IGF1,IGFI,IGFIA,MGF
    Uniprot AccessionP05019,P08025,P33712,P07455,P51458
    Uniprot Entry NameIGF1_HUMAN,IGF1_RAT,IGF1_CANLF,IGF1_BOVIN,IGF1_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseProstate Cancer
    Gene EnsemblENSG00000017427
    Target ClassificationN/A

    The target: IGF1, gene name: IGF1, also named as IGF, IGF-I, IGFI, MGF. The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.