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Anti-PDCD1/ PD-1/ CD279 monoclonal antibody
Anti-PDCD1/ PD-1/ CD279 antibody for FACS & in-vivo assay
Go to PD-1/PDCD1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59631-Ab-1/ GM-Tg-hg-T59631-Ab-2 | Anti-Human PD-1/PDCD1 monoclonal antibody | Human |
| GM-Tg-rg-T59631-Ab-1/ GM-Tg-rg-T59631-Ab-2 | Anti-Rat PD-1/PDCD1 monoclonal antibody | Rat |
| GM-Tg-mg-T59631-Ab-1/ GM-Tg-mg-T59631-Ab-2 | Anti-Mouse PD-1/PDCD1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T59631-Ab-1/ GM-Tg-cynog-T59631-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PD-1/PDCD1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59631-Ab-1/ GM-Tg-felg-T59631-Ab-2 | Anti-Feline PD-1/PDCD1 monoclonal antibody | Feline |
| GM-Tg-cang-T59631-Ab-1/ GM-Tg-cang-T59631-Ab-2 | Anti-Canine PD-1/PDCD1 monoclonal antibody | Canine |
| GM-Tg-bovg-T59631-Ab-1/ GM-Tg-bovg-T59631-Ab-2 | Anti-Bovine PD-1/PDCD1 monoclonal antibody | Bovine |
| GM-Tg-equg-T59631-Ab-1/ GM-Tg-equg-T59631-Ab-2 | Anti-Equine PD-1/PDCD1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59631-Ab-1/ GM-Tg-hg-T59631-Ab-2; GM-Tg-rg-T59631-Ab-1/ GM-Tg-rg-T59631-Ab-2; GM-Tg-mg-T59631-Ab-1/ GM-Tg-mg-T59631-Ab-2; GM-Tg-cynog-T59631-Ab-1/ GM-Tg-cynog-T59631-Ab-2; GM-Tg-felg-T59631-Ab-1/ GM-Tg-felg-T59631-Ab-2; GM-Tg-cang-T59631-Ab-1/ GM-Tg-cang-T59631-Ab-2; GM-Tg-bovg-T59631-Ab-1/ GM-Tg-bovg-T59631-Ab-2; GM-Tg-equg-T59631-Ab-1/ GM-Tg-equg-T59631-Ab-2 |
| Products Name | Anti-PD-1/PDCD1 monoclonal antibody |
| Format | mab |
| Target Name | PD-1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PD-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
| Target ID | GM-T59631 |
| Target Name | PD-1 |
| Gene ID | 5133,18566,301626,100135775,486213,100135770,613842,100067948 |
| Gene Symbol and Synonyms | CD279,hPD-1,hPD-l,hSLE1,Ly101,PD-1,PD1,Pdc1,PDCD1,SLEB2 |
| Uniprot Accession | Q15116 |
| Uniprot Entry Name | PDCD1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000188389 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: PD-1, gene name: PDCD1, also named as CD279, PD-1, PD1, SLEB2, hPD-1, hPD-l, hSLE1. Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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