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Human PDCD1/CD279/hPD-1 ORF/cDNA clone-Lentivirus plasmid (NM_005018.1)
Cat. No.: pGMLV000709
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days
Pre-made Human PDCD1/CD279/hPD-1 Lentiviral expression plasmid for PDCD1 lentivirus packaging, PDCD1 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.
Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.
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Product Description
| Catalog ID | pGMLV000709 |
| Gene Name | PDCD1 |
| Accession Number | NM_005018.1 |
| Gene ID | 5133 |
| Species | Human |
| Product Type | Lentivirus plasmid (overexpression) |
| Insert Length | 867 bp |
| Gene Alias | CD279,hPD-1,hPD-l,PD1,SLEB2 |
| Fluorescent Reporter | ZsGreen |
| Mammalian Cell Selection | Blasticidin (BSD) |
| Fusion Tag | 3xflag (C-Terminal) |
| Promoter | CMV |
| Resistance | Amplicin |
Reference
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Associated products
Target information
| Target ID | GM-T59631 |
| Target Name | PD-1 |
| Gene ID | 5133, 18566, 100135775, 301626, 100135770, 486213, 613842, 100067948 |
| Gene Symbol and Synonyms | CD279,hPD-1,hPD-l,hSLE1,Ly101,PD-1,PD1,Pdc1,PDCD1,SLEB2 |
| Uniprot Accession | Q15116 |
| Uniprot Entry Name | PDCD1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index |
| Disease | Cancer |
| Gene Ensembl | ENSG00000188389 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
About GMVC
GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.
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