Anti-NQO1 monoclonal antibody
Pre-made anti-NQO1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T52389-Ab-1/ GM-Tg-hg-T52389-Ab-2 | Anti-Human NQO1 monoclonal antibody | Human |
GM-Tg-rg-T52389-Ab-1/ GM-Tg-rg-T52389-Ab-2 | Anti-Rat NQO1 monoclonal antibody | Rat |
GM-Tg-mg-T52389-Ab-1/ GM-Tg-mg-T52389-Ab-2 | Anti-Mouse NQO1 monoclonal antibody | Mouse |
GM-Tg-cynog-T52389-Ab-1/ GM-Tg-cynog-T52389-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NQO1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T52389-Ab-1/ GM-Tg-felg-T52389-Ab-2 | Anti-Feline NQO1 monoclonal antibody | Feline |
GM-Tg-cang-T52389-Ab-1/ GM-Tg-cang-T52389-Ab-2 | Anti-Canine NQO1 monoclonal antibody | Canine |
GM-Tg-bovg-T52389-Ab-1/ GM-Tg-bovg-T52389-Ab-2 | Anti-Bovine NQO1 monoclonal antibody | Bovine |
GM-Tg-equg-T52389-Ab-1/ GM-Tg-equg-T52389-Ab-2 | Anti-Equine NQO1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T52389-Ab-1/ GM-Tg-hg-T52389-Ab-2; GM-Tg-rg-T52389-Ab-1/ GM-Tg-rg-T52389-Ab-2; GM-Tg-mg-T52389-Ab-1/ GM-Tg-mg-T52389-Ab-2; GM-Tg-cynog-T52389-Ab-1/ GM-Tg-cynog-T52389-Ab-2; GM-Tg-felg-T52389-Ab-1/ GM-Tg-felg-T52389-Ab-2; GM-Tg-cang-T52389-Ab-1/ GM-Tg-cang-T52389-Ab-2; GM-Tg-bovg-T52389-Ab-1/ GM-Tg-bovg-T52389-Ab-2; GM-Tg-equg-T52389-Ab-1/ GM-Tg-equg-T52389-Ab-2 |
Products Name | Anti-NQO1 monoclonal antibody |
Format | mab |
Target Name | NQO1 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-NQO1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T52389-Ag-1 | Recombinant multi-species NQO1/ DHQU/ DIA4 protein |
ORF Viral Vector | vGMLV000811 | human NQO1 Lentivirus particle |
ORF Viral Vector | pGMLV000811 | human NQO1 Lentivirus plasmid |
ORF Viral Vector | pGMLP000898 | human NQO1 Lentivirus plasmid |
ORF Viral Vector | vGMLP000898 | human NQO1 Lentivirus particle |
ORF Viral Vector | pGMLPm000830 | mouse Nqo1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm000830 | mouse Nqo1 Lentivirus particle |
Target information
Target ID | GM-T52389 |
Target Name | NQO1 |
Gene ID | 1728,18104,24314,705635,610935,101097859,519632,100067237 |
Gene Symbol and Synonyms | DHQU,DIA4,DTD,Nmo-1,Nmo1,NMOR1,NMORI,NQO1,Ox-1,Ox1,QR1 |
Uniprot Accession | P15559,P05982 |
Uniprot Entry Name | NQO1_HUMAN,NQO1_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000181019 |
Target Classification | Tumor-associated antigen (TAA) |
The target: NQO1, gene name: NQO1, also named as DHQU, DIA4, DTD, NMOR1, NMORI, QR1. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.