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Anti-SH2B3 monoclonal antibody
Pre-made anti-SH2B3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SH2B3/SH2B3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T44585-Ab-1/ GM-Tg-hg-T44585-Ab-2 | Anti-Human SH2B3 monoclonal antibody | Human |
| GM-Tg-rg-T44585-Ab-1/ GM-Tg-rg-T44585-Ab-2 | Anti-Rat SH2B3 monoclonal antibody | Rat |
| GM-Tg-mg-T44585-Ab-1/ GM-Tg-mg-T44585-Ab-2 | Anti-Mouse SH2B3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T44585-Ab-1/ GM-Tg-cynog-T44585-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SH2B3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T44585-Ab-1/ GM-Tg-felg-T44585-Ab-2 | Anti-Feline SH2B3 monoclonal antibody | Feline |
| GM-Tg-cang-T44585-Ab-1/ GM-Tg-cang-T44585-Ab-2 | Anti-Canine SH2B3 monoclonal antibody | Canine |
| GM-Tg-bovg-T44585-Ab-1/ GM-Tg-bovg-T44585-Ab-2 | Anti-Bovine SH2B3 monoclonal antibody | Bovine |
| GM-Tg-equg-T44585-Ab-1/ GM-Tg-equg-T44585-Ab-2 | Anti-Equine SH2B3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T44585-Ab-1/ GM-Tg-hg-T44585-Ab-2; GM-Tg-rg-T44585-Ab-1/ GM-Tg-rg-T44585-Ab-2; GM-Tg-mg-T44585-Ab-1/ GM-Tg-mg-T44585-Ab-2; GM-Tg-cynog-T44585-Ab-1/ GM-Tg-cynog-T44585-Ab-2; GM-Tg-felg-T44585-Ab-1/ GM-Tg-felg-T44585-Ab-2; GM-Tg-cang-T44585-Ab-1/ GM-Tg-cang-T44585-Ab-2; GM-Tg-bovg-T44585-Ab-1/ GM-Tg-bovg-T44585-Ab-2; GM-Tg-equg-T44585-Ab-1/ GM-Tg-equg-T44585-Ab-2 |
| Products Name | Anti-SH2B3 monoclonal antibody |
| Format | mab |
| Target Name | SH2B3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SH2B3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T44585-Ag-1 | Recombinant multi-species SH2B3/ IDDM20/ LNK protein |
| ORF Viral Vector | vGMLV000209 | human SH2B3 Lentivirus particle |
| ORF Viral Vector | pGMLV000209 | human SH2B3 Lentivirus plasmid |
Target information
| Target ID | GM-T44585 |
| Target Name | SH2B3 |
| Gene ID | 10019,16923,58838,710839,100683018,101081760,614726,100057885 |
| Gene Symbol and Synonyms | IDDM20,LNK,SH2B3 |
| Uniprot Accession | Q9UQQ2,P50745 |
| Uniprot Entry Name | SH2B3_HUMAN,SH2B3_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000111252 |
| Target Classification | N/A |
The target: SH2B3, gene name: SH2B3, also named as IDDM20, LNK. This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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