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Anti-SMAD3 monoclonal antibody
Pre-made anti-SMAD3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SMAD3/SMAD3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T35445-Ab-1/ GM-Tg-hg-T35445-Ab-2 | Anti-Human SMAD3 monoclonal antibody | Human |
| GM-Tg-rg-T35445-Ab-1/ GM-Tg-rg-T35445-Ab-2 | Anti-Rat SMAD3 monoclonal antibody | Rat |
| GM-Tg-mg-T35445-Ab-1/ GM-Tg-mg-T35445-Ab-2 | Anti-Mouse SMAD3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T35445-Ab-1/ GM-Tg-cynog-T35445-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SMAD3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T35445-Ab-1/ GM-Tg-felg-T35445-Ab-2 | Anti-Feline SMAD3 monoclonal antibody | Feline |
| GM-Tg-cang-T35445-Ab-1/ GM-Tg-cang-T35445-Ab-2 | Anti-Canine SMAD3 monoclonal antibody | Canine |
| GM-Tg-bovg-T35445-Ab-1/ GM-Tg-bovg-T35445-Ab-2 | Anti-Bovine SMAD3 monoclonal antibody | Bovine |
| GM-Tg-equg-T35445-Ab-1/ GM-Tg-equg-T35445-Ab-2 | Anti-Equine SMAD3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T35445-Ab-1/ GM-Tg-hg-T35445-Ab-2; GM-Tg-rg-T35445-Ab-1/ GM-Tg-rg-T35445-Ab-2; GM-Tg-mg-T35445-Ab-1/ GM-Tg-mg-T35445-Ab-2; GM-Tg-cynog-T35445-Ab-1/ GM-Tg-cynog-T35445-Ab-2; GM-Tg-felg-T35445-Ab-1/ GM-Tg-felg-T35445-Ab-2; GM-Tg-cang-T35445-Ab-1/ GM-Tg-cang-T35445-Ab-2; GM-Tg-bovg-T35445-Ab-1/ GM-Tg-bovg-T35445-Ab-2; GM-Tg-equg-T35445-Ab-1/ GM-Tg-equg-T35445-Ab-2 |
| Products Name | Anti-SMAD3 monoclonal antibody |
| Format | mab |
| Target Name | SMAD3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SMAD3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T35445-Ag-1 | Recombinant multi-species SMAD3/ HSPC193/ HsT17436 protein |
| Cytokine | GM-Tg-g-T35445-Ag-1 | SMAD family member 3 (SMAD3) protein |
| ORF Viral Vector | pGMAP000252 | Human SMAD3 Adenovirus plasmid |
| ORF Viral Vector | pGMLP000019 | human SMAD3 Lentivirus plasmid |
| ORF Viral Vector | vGMAP000252 | Human SMAD3 Adenovirus particle |
| ORF Viral Vector | vGMLP000019 | human SMAD3 Lentivirus particle |
Target information
| Target ID | GM-T35445 |
| Target Name | SMAD3 |
| Gene ID | 4088,17127,25631,711355,610902,101101387,515125,100033845 |
| Gene Symbol and Synonyms | hMAD-3,hSMAD3,HSPC193,HsT17436,JV15-2,LDS1C,LDS3,mad3,MADH3,Smad 3,SMAD3 |
| Uniprot Accession | P84022,P84025 |
| Uniprot Entry Name | SMAD3_HUMAN,SMAD3_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000166949 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SMAD3, gene name: SMAD3, also named as HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3. The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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