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Anti-PA21B/ PLA2G1B/ PLA2 functional antibody
Anti-PA21B/ PLA2G1B/ PLA2 functional antibody for cell culture, ELISA & in-vivo assay
Go to PLA2G1B/PLA2G1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T31479-Ab-1/ GM-Tg-hg-T31479-Ab-2 | Anti-Human PLA2G1B monoclonal antibody | Human |
| GM-Tg-rg-T31479-Ab-1/ GM-Tg-rg-T31479-Ab-2 | Anti-Rat PLA2G1B monoclonal antibody | Rat |
| GM-Tg-mg-T31479-Ab-1/ GM-Tg-mg-T31479-Ab-2 | Anti-Mouse PLA2G1B monoclonal antibody | Mouse |
| GM-Tg-cynog-T31479-Ab-1/ GM-Tg-cynog-T31479-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLA2G1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T31479-Ab-1/ GM-Tg-felg-T31479-Ab-2 | Anti-Feline PLA2G1B monoclonal antibody | Feline |
| GM-Tg-cang-T31479-Ab-1/ GM-Tg-cang-T31479-Ab-2 | Anti-Canine PLA2G1B monoclonal antibody | Canine |
| GM-Tg-bovg-T31479-Ab-1/ GM-Tg-bovg-T31479-Ab-2 | Anti-Bovine PLA2G1B monoclonal antibody | Bovine |
| GM-Tg-equg-T31479-Ab-1/ GM-Tg-equg-T31479-Ab-2 | Anti-Equine PLA2G1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T31479-Ab-1/ GM-Tg-hg-T31479-Ab-2; GM-Tg-rg-T31479-Ab-1/ GM-Tg-rg-T31479-Ab-2; GM-Tg-mg-T31479-Ab-1/ GM-Tg-mg-T31479-Ab-2; GM-Tg-cynog-T31479-Ab-1/ GM-Tg-cynog-T31479-Ab-2; GM-Tg-felg-T31479-Ab-1/ GM-Tg-felg-T31479-Ab-2; GM-Tg-cang-T31479-Ab-1/ GM-Tg-cang-T31479-Ab-2; GM-Tg-bovg-T31479-Ab-1/ GM-Tg-bovg-T31479-Ab-2; GM-Tg-equg-T31479-Ab-1/ GM-Tg-equg-T31479-Ab-2 |
| Products Name | Anti-PLA2G1B monoclonal antibody |
| Format | mab |
| Target Name | PLA2G1B |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLA2G1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T31479-Ag-1 | Recombinant multi-species PA21B/ PLA2G1B/ PLA2 protein |
| ORF Viral Vector | vGMLP002399 | human PLA2G1B Lentivirus particle |
| ORF Viral Vector | pGMLP002399 | human PLA2G1B Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002212 | mouse Pla2g1b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002212 | mouse Pla2g1b Lentivirus particle |
Target information
| Target ID | GM-T31479 |
| Target Name | PLA2G1B |
| Gene ID | 5319,18778,29526,696712,404011,101095522,282457,100050467 |
| Gene Symbol and Synonyms | PLA2,PLA2A,PLA2G1B,PPLA2,sPLA2IB |
| Uniprot Accession | P04054,P04055,P06596,P00593,P00594 |
| Uniprot Entry Name | PA21B_HUMAN,PA21B_RAT,PA21B_CANLF,PA21B_BOVIN,PA21B_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000170890 |
| Target Classification | N/A |
The target: PLA2G1B, gene name: PLA2G1B, also named as PLA2, PLA2A, PPLA2. This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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