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Anti-CCL22/ MDC/ A-152E5.1 functional antibody
Anti-CCL22/ MDC/ A-152E5.1 functional antibody for cell culture, ELISA & in-vivo assay
Go to MDC/CCL22 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T22117-Ab-1/ GM-Tg-hg-T22117-Ab-2 | Anti-Human MDC/CCL22 monoclonal antibody | Human |
| GM-Tg-rg-T22117-Ab-1/ GM-Tg-rg-T22117-Ab-2 | Anti-Rat MDC/CCL22 monoclonal antibody | Rat |
| GM-Tg-mg-T22117-Ab-1/ GM-Tg-mg-T22117-Ab-2 | Anti-Mouse MDC/CCL22 monoclonal antibody | Mouse |
| GM-Tg-cynog-T22117-Ab-1/ GM-Tg-cynog-T22117-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MDC/CCL22 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T22117-Ab-1/ GM-Tg-felg-T22117-Ab-2 | Anti-Feline MDC/CCL22 monoclonal antibody | Feline |
| GM-Tg-cang-T22117-Ab-1/ GM-Tg-cang-T22117-Ab-2 | Anti-Canine MDC/CCL22 monoclonal antibody | Canine |
| GM-Tg-bovg-T22117-Ab-1/ GM-Tg-bovg-T22117-Ab-2 | Anti-Bovine MDC/CCL22 monoclonal antibody | Bovine |
| GM-Tg-equg-T22117-Ab-1/ GM-Tg-equg-T22117-Ab-2 | Anti-Equine MDC/CCL22 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T22117-Ab-1/ GM-Tg-hg-T22117-Ab-2; GM-Tg-rg-T22117-Ab-1/ GM-Tg-rg-T22117-Ab-2; GM-Tg-mg-T22117-Ab-1/ GM-Tg-mg-T22117-Ab-2; GM-Tg-cynog-T22117-Ab-1/ GM-Tg-cynog-T22117-Ab-2; GM-Tg-felg-T22117-Ab-1/ GM-Tg-felg-T22117-Ab-2; GM-Tg-cang-T22117-Ab-1/ GM-Tg-cang-T22117-Ab-2; GM-Tg-bovg-T22117-Ab-1/ GM-Tg-bovg-T22117-Ab-2; GM-Tg-equg-T22117-Ab-1/ GM-Tg-equg-T22117-Ab-2 |
| Products Name | Anti-MDC/CCL22 monoclonal antibody |
| Format | mab |
| Target Name | MDC |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MDC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T22117-Ag-1 | Recombinant multi-species CCL22/ MDC/ A-152E5.1 protein |
| Cytokine | GM-Tg-g-T22117-Ag-1 | chemokine (C-C motif) ligand 22 (CCL22) protein |
| ORF Viral Vector | vGMLP002730 | human CCL22 Lentivirus particle |
| ORF Viral Vector | pGMLP002730 | human CCL22 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000043 | mouse Ccl22 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000043 | mouse Ccl22 Lentivirus particle |
Target information
| Target ID | GM-T22117 |
| Target Name | MDC |
| Gene ID | 6367,20299,117551,100428046,100686212,101091326,616996,100062332 |
| Gene Symbol and Synonyms | A-152E5.1,ABCD-1,CCL22,DC/B-CK,DCBCK,MDC,SCYA22,STCP-1 |
| Uniprot Accession | O00626 |
| Uniprot Entry Name | CCL22_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000102962 |
| Target Classification | N/A |
The target: MDC, gene name: CCL22, also named as A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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