Anti-CCL22/ MDC/ A-152E5.1 functional antibody

Anti-CCL22/ MDC/ A-152E5.1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to MDC/CCL22 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T22117-Ab-1/ GM-Tg-hg-T22117-Ab-2Anti-Human MDC/CCL22 monoclonal antibodyHuman
GM-Tg-rg-T22117-Ab-1/ GM-Tg-rg-T22117-Ab-2Anti-Rat MDC/CCL22 monoclonal antibodyRat
GM-Tg-mg-T22117-Ab-1/ GM-Tg-mg-T22117-Ab-2Anti-Mouse MDC/CCL22 monoclonal antibodyMouse
GM-Tg-cynog-T22117-Ab-1/ GM-Tg-cynog-T22117-Ab-2Anti-Cynomolgus/ Rhesus macaque MDC/CCL22 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T22117-Ab-1/ GM-Tg-felg-T22117-Ab-2Anti-Feline MDC/CCL22 monoclonal antibodyFeline
GM-Tg-cang-T22117-Ab-1/ GM-Tg-cang-T22117-Ab-2Anti-Canine MDC/CCL22 monoclonal antibodyCanine
GM-Tg-bovg-T22117-Ab-1/ GM-Tg-bovg-T22117-Ab-2Anti-Bovine MDC/CCL22 monoclonal antibodyBovine
GM-Tg-equg-T22117-Ab-1/ GM-Tg-equg-T22117-Ab-2Anti-Equine MDC/CCL22 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T22117-Ab-1/ GM-Tg-hg-T22117-Ab-2; GM-Tg-rg-T22117-Ab-1/ GM-Tg-rg-T22117-Ab-2;
GM-Tg-mg-T22117-Ab-1/ GM-Tg-mg-T22117-Ab-2; GM-Tg-cynog-T22117-Ab-1/ GM-Tg-cynog-T22117-Ab-2;
GM-Tg-felg-T22117-Ab-1/ GM-Tg-felg-T22117-Ab-2; GM-Tg-cang-T22117-Ab-1/ GM-Tg-cang-T22117-Ab-2;
GM-Tg-bovg-T22117-Ab-1/ GM-Tg-bovg-T22117-Ab-2; GM-Tg-equg-T22117-Ab-1/ GM-Tg-equg-T22117-Ab-2
Products NameAnti-MDC/CCL22 monoclonal antibody
Formatmab
Target NameMDC
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MDC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T22117-Ag-1Recombinant multi-species CCL22/ MDC/ A-152E5.1 protein
    CytokineGM-Tg-g-T22117-Ag-1chemokine (C-C motif) ligand 22 (CCL22) protein
    ORF Viral VectorvGMLP002730human CCL22 Lentivirus particle
    ORF Viral VectorpGMLP002730human CCL22 Lentivirus plasmid
    ORF Viral VectorpGMLPm000043mouse Ccl22 Lentivirus plasmid
    ORF Viral VectorvGMLPm000043mouse Ccl22 Lentivirus particle


    Target information

    Target IDGM-T22117
    Target NameMDC
    Gene ID6367,20299,117551,100428046,100686212,101091326,616996,100062332
    Gene Symbol and SynonymsA-152E5.1,ABCD-1,CCL22,DC/B-CK,DCBCK,MDC,SCYA22,STCP-1
    Uniprot AccessionO00626
    Uniprot Entry NameCCL22_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000102962
    Target ClassificationN/A

    The target: MDC, gene name: CCL22, also named as A-152E5.1, ABCD-1, DC/B-CK, MDC, SCYA22, STCP-1. This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.