Anti-HNMT monoclonal antibody

Pre-made anti-HNMT monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to HNMT/HNMT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T17448-Ab-1/ GM-Tg-hg-T17448-Ab-2Anti-Human HNMT monoclonal antibodyHuman
GM-Tg-rg-T17448-Ab-1/ GM-Tg-rg-T17448-Ab-2Anti-Rat HNMT monoclonal antibodyRat
GM-Tg-mg-T17448-Ab-1/ GM-Tg-mg-T17448-Ab-2Anti-Mouse HNMT monoclonal antibodyMouse
GM-Tg-cynog-T17448-Ab-1/ GM-Tg-cynog-T17448-Ab-2Anti-Cynomolgus/ Rhesus macaque HNMT monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T17448-Ab-1/ GM-Tg-felg-T17448-Ab-2Anti-Feline HNMT monoclonal antibodyFeline
GM-Tg-cang-T17448-Ab-1/ GM-Tg-cang-T17448-Ab-2Anti-Canine HNMT monoclonal antibodyCanine
GM-Tg-bovg-T17448-Ab-1/ GM-Tg-bovg-T17448-Ab-2Anti-Bovine HNMT monoclonal antibodyBovine
GM-Tg-equg-T17448-Ab-1/ GM-Tg-equg-T17448-Ab-2Anti-Equine HNMT monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T17448-Ab-1/ GM-Tg-hg-T17448-Ab-2; GM-Tg-rg-T17448-Ab-1/ GM-Tg-rg-T17448-Ab-2;
GM-Tg-mg-T17448-Ab-1/ GM-Tg-mg-T17448-Ab-2; GM-Tg-cynog-T17448-Ab-1/ GM-Tg-cynog-T17448-Ab-2;
GM-Tg-felg-T17448-Ab-1/ GM-Tg-felg-T17448-Ab-2; GM-Tg-cang-T17448-Ab-1/ GM-Tg-cang-T17448-Ab-2;
GM-Tg-bovg-T17448-Ab-1/ GM-Tg-bovg-T17448-Ab-2; GM-Tg-equg-T17448-Ab-1/ GM-Tg-equg-T17448-Ab-2
Products NameAnti-HNMT monoclonal antibody
Formatmab
Target NameHNMT
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-HNMT monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T17448-Ag-1Recombinant multi-species HNMT/ HMT-S1/ HNMT-S2 protein
    ORF Viral VectorvGMLP003955human HNMT Lentivirus particle
    ORF Viral VectorpGMLP003955human HNMT Lentivirus plasmid
    ORF Viral VectorpGMLPm002592mouse Hnmt Lentivirus plasmid
    ORF Viral VectorvGMLPm002592mouse Hnmt Lentivirus particle


    Target information

    Target IDGM-T17448
    Target NameHNMT
    Gene ID3176,140483,81676,476133,101093704,613413,100051119
    Gene Symbol and Synonyms1500031F01Rik,HMT,HNMT,HNMT-S1,HNMT-S2,MRT51
    Uniprot AccessionP50135,Q01984,Q58DV7
    Uniprot Entry NameHNMT_HUMAN,HNMT_RAT,HNMT_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000150540
    Target ClassificationN/A

    The target: HNMT, gene name: HNMT, also named as HMT-S1, HNMT-S2, MRT51, HNMT. In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.