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Anti-HNMT monoclonal antibody
Pre-made anti-HNMT monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HNMT/HNMT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T17448-Ab-1/ GM-Tg-hg-T17448-Ab-2 | Anti-Human HNMT monoclonal antibody | Human |
| GM-Tg-rg-T17448-Ab-1/ GM-Tg-rg-T17448-Ab-2 | Anti-Rat HNMT monoclonal antibody | Rat |
| GM-Tg-mg-T17448-Ab-1/ GM-Tg-mg-T17448-Ab-2 | Anti-Mouse HNMT monoclonal antibody | Mouse |
| GM-Tg-cynog-T17448-Ab-1/ GM-Tg-cynog-T17448-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HNMT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T17448-Ab-1/ GM-Tg-felg-T17448-Ab-2 | Anti-Feline HNMT monoclonal antibody | Feline |
| GM-Tg-cang-T17448-Ab-1/ GM-Tg-cang-T17448-Ab-2 | Anti-Canine HNMT monoclonal antibody | Canine |
| GM-Tg-bovg-T17448-Ab-1/ GM-Tg-bovg-T17448-Ab-2 | Anti-Bovine HNMT monoclonal antibody | Bovine |
| GM-Tg-equg-T17448-Ab-1/ GM-Tg-equg-T17448-Ab-2 | Anti-Equine HNMT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T17448-Ab-1/ GM-Tg-hg-T17448-Ab-2; GM-Tg-rg-T17448-Ab-1/ GM-Tg-rg-T17448-Ab-2; GM-Tg-mg-T17448-Ab-1/ GM-Tg-mg-T17448-Ab-2; GM-Tg-cynog-T17448-Ab-1/ GM-Tg-cynog-T17448-Ab-2; GM-Tg-felg-T17448-Ab-1/ GM-Tg-felg-T17448-Ab-2; GM-Tg-cang-T17448-Ab-1/ GM-Tg-cang-T17448-Ab-2; GM-Tg-bovg-T17448-Ab-1/ GM-Tg-bovg-T17448-Ab-2; GM-Tg-equg-T17448-Ab-1/ GM-Tg-equg-T17448-Ab-2 |
| Products Name | Anti-HNMT monoclonal antibody |
| Format | mab |
| Target Name | HNMT |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HNMT monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T17448-Ag-1 | Recombinant multi-species HNMT/ HMT-S1/ HNMT-S2 protein |
| ORF Viral Vector | vGMLP003955 | human HNMT Lentivirus particle |
| ORF Viral Vector | pGMLP003955 | human HNMT Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002592 | mouse Hnmt Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002592 | mouse Hnmt Lentivirus particle |
Target information
| Target ID | GM-T17448 |
| Target Name | HNMT |
| Gene ID | 3176,140483,81676,476133,101093704,613413,100051119 |
| Gene Symbol and Synonyms | 1500031F01Rik,HMT,HNMT,HNMT-S1,HNMT-S2,MRT51 |
| Uniprot Accession | P50135,Q01984,Q58DV7 |
| Uniprot Entry Name | HNMT_HUMAN,HNMT_RAT,HNMT_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000150540 |
| Target Classification | N/A |
The target: HNMT, gene name: HNMT, also named as HMT-S1, HNMT-S2, MRT51, HNMT. In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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