Anti-ILRL2/ IL1RL2/ IL-1Rrp2 monoclonal antibody

Anti-ILRL2/ IL1RL2/ IL-1Rrp2 antibody for FACS & in-vivo assay

Target products collectionGo to IL1RL2/IL1RL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T10988-Ab-1/ GM-Tg-hg-T10988-Ab-2Anti-Human IL1RL2 monoclonal antibodyHuman
GM-Tg-rg-T10988-Ab-1/ GM-Tg-rg-T10988-Ab-2Anti-Rat IL1RL2 monoclonal antibodyRat
GM-Tg-mg-T10988-Ab-1/ GM-Tg-mg-T10988-Ab-2Anti-Mouse IL1RL2 monoclonal antibodyMouse
GM-Tg-cynog-T10988-Ab-1/ GM-Tg-cynog-T10988-Ab-2Anti-Cynomolgus/ Rhesus macaque IL1RL2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T10988-Ab-1/ GM-Tg-felg-T10988-Ab-2Anti-Feline IL1RL2 monoclonal antibodyFeline
GM-Tg-cang-T10988-Ab-1/ GM-Tg-cang-T10988-Ab-2Anti-Canine IL1RL2 monoclonal antibodyCanine
GM-Tg-bovg-T10988-Ab-1/ GM-Tg-bovg-T10988-Ab-2Anti-Bovine IL1RL2 monoclonal antibodyBovine
GM-Tg-equg-T10988-Ab-1/ GM-Tg-equg-T10988-Ab-2Anti-Equine IL1RL2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T10988-Ab-1/ GM-Tg-hg-T10988-Ab-2; GM-Tg-rg-T10988-Ab-1/ GM-Tg-rg-T10988-Ab-2;
GM-Tg-mg-T10988-Ab-1/ GM-Tg-mg-T10988-Ab-2; GM-Tg-cynog-T10988-Ab-1/ GM-Tg-cynog-T10988-Ab-2;
GM-Tg-felg-T10988-Ab-1/ GM-Tg-felg-T10988-Ab-2; GM-Tg-cang-T10988-Ab-1/ GM-Tg-cang-T10988-Ab-2;
GM-Tg-bovg-T10988-Ab-1/ GM-Tg-bovg-T10988-Ab-2; GM-Tg-equg-T10988-Ab-1/ GM-Tg-equg-T10988-Ab-2
Products NameAnti-IL1RL2 monoclonal antibody
Formatmab
Target NameIL1RL2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL1RL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-799Pre-Made Denileukin Diftitox Biosimilar, Fusion Protein targeting IL1RL2 fused with human IL2 (interleukin 2, IL-2): Recombinant therapeutic protein targeting IL-1Rrp2/IL-36R/IL1R-rp2/IL1RRP2
    BiosimilarGMP-Bios-ab-269Pre-Made Imsidolimab biosimilar, Whole mAb, Anti-IL36R/IL1RL2 Antibody: Anti-IL1RRP2/IL-1Rrp2/IL1R-rp2 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ILRL2/ IL1RL2/ IL-1Rrp2 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T10988-Ag-1IL-1 R6 (IL1RL2) protein


    Target information

    Target IDGM-T10988
    Target NameIL1RL2
    Gene ID8808,107527,171106,711812,611453,101085113,522114,100058487
    Gene Symbol and SynonymsIL-1Rrp2,IL-36R,IL1R-rp2,IL1RL2,IL1RRP2
    Uniprot AccessionQ9HB29,Q62929
    Uniprot Entry NameILRL2_HUMAN,ILRL2_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000115598
    Target ClassificationN/A

    The target: IL1RL2, gene name: IL1RL2, also named as IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2. The protein encoded by this gene is a member of the interleukin 1 receptor family. An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. This gene and four other interleukin 1 receptor family genes, including interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 1 (IL1RL1), and interleukin 18 receptor 1 (IL18R1), form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.