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Anti-TINF2/ DKCA3/ TIN2 functional antibody
Anti-TINF2/ DKCA3/ TIN2 functional antibody for cell culture, ELISA & in-vivo assay
Go to TINF2/TINF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1433-Ab-1/ GM-Tg-hg-SE1433-Ab-2 | Anti-Human TINF2 monoclonal antibody | Human |
| GM-Tg-rg-SE1433-Ab-1/ GM-Tg-rg-SE1433-Ab-2 | Anti-Rat TINF2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1433-Ab-1/ GM-Tg-mg-SE1433-Ab-2 | Anti-Mouse TINF2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1433-Ab-1/ GM-Tg-cynog-SE1433-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TINF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1433-Ab-1/ GM-Tg-felg-SE1433-Ab-2 | Anti-Feline TINF2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1433-Ab-1/ GM-Tg-cang-SE1433-Ab-2 | Anti-Canine TINF2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1433-Ab-1/ GM-Tg-bovg-SE1433-Ab-2 | Anti-Bovine TINF2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1433-Ab-1/ GM-Tg-equg-SE1433-Ab-2 | Anti-Equine TINF2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1433-Ab-1/ GM-Tg-hg-SE1433-Ab-2; GM-Tg-rg-SE1433-Ab-1/ GM-Tg-rg-SE1433-Ab-2; GM-Tg-mg-SE1433-Ab-1/ GM-Tg-mg-SE1433-Ab-2; GM-Tg-cynog-SE1433-Ab-1/ GM-Tg-cynog-SE1433-Ab-2; GM-Tg-felg-SE1433-Ab-1/ GM-Tg-felg-SE1433-Ab-2; GM-Tg-cang-SE1433-Ab-1/ GM-Tg-cang-SE1433-Ab-2; GM-Tg-bovg-SE1433-Ab-1/ GM-Tg-bovg-SE1433-Ab-2; GM-Tg-equg-SE1433-Ab-1/ GM-Tg-equg-SE1433-Ab-2 |
| Products Name | Anti-TINF2 monoclonal antibody |
| Format | mab |
| Target Name | TINF2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TINF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1433-Ag-1 | Recombinant multi-species TINF2/ DKCA3/ TIN2 protein |
| ORF Viral Vector | vGMLP000118 | human TINF2 Lentivirus particle |
| ORF Viral Vector | pGMLP000118 | human TINF2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001433 | mouse Tinf2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001433 | mouse Tinf2 Lentivirus particle |
Target information
| Target ID | GM-SE1433 |
| Target Name | TINF2 |
| Gene ID | 26277,28113,290232,715812,608377,101081811,540420,100054625 |
| Gene Symbol and Synonyms | D14Wsu146e,DKCA3,TIN2,TINF2 |
| Uniprot Accession | Q9BSI4 |
| Uniprot Entry Name | TINF2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000092330 |
| Target Classification | N/A |
The target: TINF2, gene name: TINF2, also named as DKCA3, TIN2. This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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