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Anti-GREM2/ CKTSF1B2/ DAND3 functional antibody
Anti-GREM2/ CKTSF1B2/ DAND3 functional antibody for cell culture, ELISA & in-vivo assay
Go to GREM2/GREM2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0959-Ab-1/ GM-Tg-hg-SE0959-Ab-2 | Anti-Human GREM2 monoclonal antibody | Human |
| GM-Tg-rg-SE0959-Ab-1/ GM-Tg-rg-SE0959-Ab-2 | Anti-Rat GREM2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0959-Ab-1/ GM-Tg-mg-SE0959-Ab-2 | Anti-Mouse GREM2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0959-Ab-1/ GM-Tg-cynog-SE0959-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GREM2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0959-Ab-1/ GM-Tg-felg-SE0959-Ab-2 | Anti-Feline GREM2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0959-Ab-1/ GM-Tg-cang-SE0959-Ab-2 | Anti-Canine GREM2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0959-Ab-1/ GM-Tg-bovg-SE0959-Ab-2 | Anti-Bovine GREM2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0959-Ab-1/ GM-Tg-equg-SE0959-Ab-2 | Anti-Equine GREM2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0959-Ab-1/ GM-Tg-hg-SE0959-Ab-2; GM-Tg-rg-SE0959-Ab-1/ GM-Tg-rg-SE0959-Ab-2; GM-Tg-mg-SE0959-Ab-1/ GM-Tg-mg-SE0959-Ab-2; GM-Tg-cynog-SE0959-Ab-1/ GM-Tg-cynog-SE0959-Ab-2; GM-Tg-felg-SE0959-Ab-1/ GM-Tg-felg-SE0959-Ab-2; GM-Tg-cang-SE0959-Ab-1/ GM-Tg-cang-SE0959-Ab-2; GM-Tg-bovg-SE0959-Ab-1/ GM-Tg-bovg-SE0959-Ab-2; GM-Tg-equg-SE0959-Ab-1/ GM-Tg-equg-SE0959-Ab-2 |
| Products Name | Anti-GREM2 monoclonal antibody |
| Format | mab |
| Target Name | GREM2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GREM2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0959-Ag-1 | Recombinant multi-species GREM2/ CKTSF1B2/ DAND3 protein |
| ORF Viral Vector | pGMLP003417 | human GREM2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003417 | human GREM2 Lentivirus particle |
| ORF Viral Vector | pGMAAV000063 | mouse Grem2 AAV plasmid |
| ORF Viral Vector | vGMAAV000063 | mouse Grem2 AAV particle |
Target information
| Target ID | GM-SE0959 |
| Target Name | GREM2 |
| Gene ID | 64388,23893,289264,708280,490367,101096531,100060243 |
| Gene Symbol and Synonyms | CKTSF1B2,DAND3,GREM2,Gremlin2,PRDC,RGD1560008,STHAG9 |
| Uniprot Accession | Q9H772 |
| Uniprot Entry Name | GREM2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000180875 |
| Target Classification | N/A |
The target: GREM2, gene name: GREM2, also named as CKTSF1B2, DAND3, PRDC, STHAG9. This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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