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Anti-ASIP/ AGSW/ AGTI functional antibody
Anti-ASIP/ AGSW/ AGTI functional antibody for cell culture, ELISA & in-vivo assay
Go to ASIP/ASIP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0681-Ab-1/ GM-Tg-hg-SE0681-Ab-2 | Anti-Human ASIP monoclonal antibody | Human |
| GM-Tg-rg-SE0681-Ab-1/ GM-Tg-rg-SE0681-Ab-2 | Anti-Rat ASIP monoclonal antibody | Rat |
| GM-Tg-mg-SE0681-Ab-1/ GM-Tg-mg-SE0681-Ab-2 | Anti-Mouse ASIP monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0681-Ab-1/ GM-Tg-cynog-SE0681-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ASIP monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0681-Ab-1/ GM-Tg-felg-SE0681-Ab-2 | Anti-Feline ASIP monoclonal antibody | Feline |
| GM-Tg-cang-SE0681-Ab-1/ GM-Tg-cang-SE0681-Ab-2 | Anti-Canine ASIP monoclonal antibody | Canine |
| GM-Tg-bovg-SE0681-Ab-1/ GM-Tg-bovg-SE0681-Ab-2 | Anti-Bovine ASIP monoclonal antibody | Bovine |
| GM-Tg-equg-SE0681-Ab-1/ GM-Tg-equg-SE0681-Ab-2 | Anti-Equine ASIP monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0681-Ab-1/ GM-Tg-hg-SE0681-Ab-2; GM-Tg-rg-SE0681-Ab-1/ GM-Tg-rg-SE0681-Ab-2; GM-Tg-mg-SE0681-Ab-1/ GM-Tg-mg-SE0681-Ab-2; GM-Tg-cynog-SE0681-Ab-1/ GM-Tg-cynog-SE0681-Ab-2; GM-Tg-felg-SE0681-Ab-1/ GM-Tg-felg-SE0681-Ab-2; GM-Tg-cang-SE0681-Ab-1/ GM-Tg-cang-SE0681-Ab-2; GM-Tg-bovg-SE0681-Ab-1/ GM-Tg-bovg-SE0681-Ab-2; GM-Tg-equg-SE0681-Ab-1/ GM-Tg-equg-SE0681-Ab-2 |
| Products Name | Anti-ASIP monoclonal antibody |
| Format | mab |
| Target Name | ASIP |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ASIP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0681-Ag-1 | Recombinant multi-species ASIP/ AGSW/ AGTI protein |
| ORF Viral Vector | vGMLP000914 | human ASIP Lentivirus particle |
| ORF Viral Vector | pGMLP000914 | human ASIP Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004542 | mouse a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004542 | mouse a Lentivirus particle |
Target information
| Target ID | GM-SE0681 |
| Target Name | ASIP |
| Gene ID | 434,50518,24152,709156,492296,492297,404192,100054335 |
| Gene Symbol and Synonyms | a,A |
| Uniprot Accession | P42127,Q99JA2,A1YL67,Q5UK76,Q865F0,Q29414,Q95MP2 |
| Uniprot Entry Name | ASIP_HUMAN,ASIP_MACMU,ASIP_RAT,ASIP_FELCA,ASIP_CANLF,ASIP_BOVIN,ASIP_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000101440 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ASIP, gene name: ASIP, also named as AGSW, AGTI, AGTIL, ASP, SHEP9. In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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