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Anti-PLOD2/ BRKS2/ LH2 functional antibody
Anti-PLOD2/ BRKS2/ LH2 functional antibody for cell culture, ELISA & in-vivo assay
Go to PLOD2/PLOD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE0415-Ab-1/ GM-Tg-hg-SE0415-Ab-2 | Anti-Human PLOD2 monoclonal antibody | Human |
| GM-Tg-rg-SE0415-Ab-1/ GM-Tg-rg-SE0415-Ab-2 | Anti-Rat PLOD2 monoclonal antibody | Rat |
| GM-Tg-mg-SE0415-Ab-1/ GM-Tg-mg-SE0415-Ab-2 | Anti-Mouse PLOD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE0415-Ab-1/ GM-Tg-cynog-SE0415-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLOD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE0415-Ab-1/ GM-Tg-felg-SE0415-Ab-2 | Anti-Feline PLOD2 monoclonal antibody | Feline |
| GM-Tg-cang-SE0415-Ab-1/ GM-Tg-cang-SE0415-Ab-2 | Anti-Canine PLOD2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE0415-Ab-1/ GM-Tg-bovg-SE0415-Ab-2 | Anti-Bovine PLOD2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE0415-Ab-1/ GM-Tg-equg-SE0415-Ab-2 | Anti-Equine PLOD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE0415-Ab-1/ GM-Tg-hg-SE0415-Ab-2; GM-Tg-rg-SE0415-Ab-1/ GM-Tg-rg-SE0415-Ab-2; GM-Tg-mg-SE0415-Ab-1/ GM-Tg-mg-SE0415-Ab-2; GM-Tg-cynog-SE0415-Ab-1/ GM-Tg-cynog-SE0415-Ab-2; GM-Tg-felg-SE0415-Ab-1/ GM-Tg-felg-SE0415-Ab-2; GM-Tg-cang-SE0415-Ab-1/ GM-Tg-cang-SE0415-Ab-2; GM-Tg-bovg-SE0415-Ab-1/ GM-Tg-bovg-SE0415-Ab-2; GM-Tg-equg-SE0415-Ab-1/ GM-Tg-equg-SE0415-Ab-2 |
| Products Name | Anti-PLOD2 monoclonal antibody |
| Format | mab |
| Target Name | PLOD2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLOD2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE0415-Ag-1 | Recombinant multi-species PLOD2/ BRKS2/ LH2 protein |
| ORF Viral Vector | pGMLV000439 | human PLOD2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000439 | human PLOD2 Lentivirus particle |
| ORF Viral Vector | pGMLPm003909 | mouse Plod2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003909 | mouse Plod2 Lentivirus particle |
Target information
| Target ID | GM-SE0415 |
| Target Name | PLOD2 |
| Gene ID | 5352,26432,300901,715820,119865413,101085741,533642,100061030 |
| Gene Symbol and Synonyms | BRKS2,D530025C14Rik,LH2,Plod-2,PLOD2,TLH |
| Uniprot Accession | O00469,Q811A3 |
| Uniprot Entry Name | PLOD2_HUMAN,PLOD2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000152952 |
| Target Classification | N/A |
The target: PLOD2, gene name: PLOD2, also named as BRKS2, LH2, TLH. The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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