Anti-FGRL1/ FGFRL1/ FGFR5 monoclonal antibody

Anti-FGRL1/ FGFRL1/ FGFR5 antibody for FACS & in-vivo assay

Target products collectionGo to FGFRL1/FGFRL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-MP0442-Ab-1/ GM-Tg-hg-MP0442-Ab-2Anti-Human FGFRL1 monoclonal antibodyHuman
GM-Tg-rg-MP0442-Ab-1/ GM-Tg-rg-MP0442-Ab-2Anti-Rat FGFRL1 monoclonal antibodyRat
GM-Tg-mg-MP0442-Ab-1/ GM-Tg-mg-MP0442-Ab-2Anti-Mouse FGFRL1 monoclonal antibodyMouse
GM-Tg-cynog-MP0442-Ab-1/ GM-Tg-cynog-MP0442-Ab-2Anti-Cynomolgus/ Rhesus macaque FGFRL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-MP0442-Ab-1/ GM-Tg-felg-MP0442-Ab-2Anti-Feline FGFRL1 monoclonal antibodyFeline
GM-Tg-cang-MP0442-Ab-1/ GM-Tg-cang-MP0442-Ab-2Anti-Canine FGFRL1 monoclonal antibodyCanine
GM-Tg-bovg-MP0442-Ab-1/ GM-Tg-bovg-MP0442-Ab-2Anti-Bovine FGFRL1 monoclonal antibodyBovine
GM-Tg-equg-MP0442-Ab-1/ GM-Tg-equg-MP0442-Ab-2Anti-Equine FGFRL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-MP0442-Ab-1/ GM-Tg-hg-MP0442-Ab-2; GM-Tg-rg-MP0442-Ab-1/ GM-Tg-rg-MP0442-Ab-2;
GM-Tg-mg-MP0442-Ab-1/ GM-Tg-mg-MP0442-Ab-2; GM-Tg-cynog-MP0442-Ab-1/ GM-Tg-cynog-MP0442-Ab-2;
GM-Tg-felg-MP0442-Ab-1/ GM-Tg-felg-MP0442-Ab-2; GM-Tg-cang-MP0442-Ab-1/ GM-Tg-cang-MP0442-Ab-2;
GM-Tg-bovg-MP0442-Ab-1/ GM-Tg-bovg-MP0442-Ab-2; GM-Tg-equg-MP0442-Ab-1/ GM-Tg-equg-MP0442-Ab-2
Products NameAnti-FGFRL1 monoclonal antibody
Formatmab
Target NameFGFRL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FGFRL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species FGRL1/ FGFRL1/ FGFR5 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-MP0442-Ag-1fibroblast growth factor receptor-like 1 (FGFRL1) protein
    ORF Viral VectorvGMLP000660human FGFRL1 Lentivirus particle
    ORF Viral VectorpGMLP000660human FGFRL1 Lentivirus plasmid
    ORF Viral VectorpGMLPm002734mouse Fgfrl1 Lentivirus plasmid
    ORF Viral VectorvGMLPm002734mouse Fgfrl1 Lentivirus particle


    Target information

    Target IDGM-MP0442
    Target NameFGFRL1
    Gene ID53834,116701,360903,702927,102151155,101095654,532327,100630904
    Gene Symbol and SynonymsFGFR-5,FGFR5,FGFR5beta,FGFR5gamma,FGFRL1,FHFR
    Uniprot AccessionQ8N441,Q7TQM3
    Uniprot Entry NameFGRL1_HUMAN,FGRL1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryCytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000127418
    Target ClassificationN/A

    The target: FGFRL1, gene name: FGFRL1, also named as FGFR5, FHFR. The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.