Human MMP2/MMP-II/MONA ORF/cDNA clone-Mammalian (Non-Viral Vector) plasmid (BC002576)

SKU: pGMPC001127
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human MMP2/MMP-II/MONA Non-Viral expression plasmid (overexpression vector) for mouse MMP2 overexpression in unique cell transient transfection and stable cell line development.

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Product Description

Catalog ID pGMPC001127
Gene Name MMP2
Accession Number BC002576
Gene ID 4313
Species Human
Product Type Mammalian (Non-Viral Vector) plasmid (overexpression)
Insert Length 1983 bp
Gene Alias MMP-II,MONA,TBE-1
Fluorescent Reporter EGFP
Mammalian Cell Selection Null
Fusion Tag 3xflag (C-Terminal)
Promoter EF1
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T68251-Ab Anti-MMP2/ MMP-2/ CLG4 monoclonal antibody
    Target Antigen GM-Tg-g-T68251-Ag MMP-2/MMP2 VLP (virus-like particle)
    ORF Viral Vector pGMLP001345 Human MMP2 Lentivirus plasmid
    ORF Viral Vector pGMLV002060 Human MMP2 Lentivirus plasmid
    ORF Viral Vector pGMAP000238 Human MMP2 Adenovirus plasmid
    ORF Viral Vector pGMPC001127 Human MMP2 Mammalian (Non-Viral Vector) plasmid
    ORF Viral Vector vGMLP001345 Human MMP2 Lentivirus particle
    ORF Viral Vector vGMLV002060 Human MMP2 Lentivirus particle
    ORF Viral Vector vGMAP000238 Human MMP2 Adenovirus particle


    Target information

    Target ID GM-T68251
    Target Name MMP-2
    Gene ID 4313, 17390, 698478, 81686, 101098838, 403733, 282872, 100033948
    Gene Symbol and Synonyms CLG4,CLG4A,GelA,MMP-2,MMP-II,MMP2,MONA,TBE-1
    Uniprot Accession P08253
    Uniprot Entry Name MMP2_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target
    Disease Ovary Cancer, Neoplasm, Type 1 diabetes mellitus, Vesicoureteral reflux, Alport syndrome, Chronic Kidney Disease, Chronic tubulo-interstitial nephritis, Malignant neoplasm of bladder, Malignant neoplasms of female genital organs
    Gene Ensembl ENSG00000087245
    Target Classification Checkpoint-Immuno Oncology

    This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]



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