Human TGFB3/ARVD/ARVD1 ORF/cDNA clone-Lentivirus plasmid (NM_003239)

SKU: pGMLP-SPh-039
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human TGFB3/ARVD/ARVD1 Lentiviral expression plasmid for TGFB3 lentivirus packaging, TGFB3 lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

Our GM-Lentiviral vector is seamlessly integrated with the GM lentivirus packaging system. Discover more about the GM lentivirus packaging system.

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Product Description

Catalog ID pGMLP-SPh-039
Gene Name TGFB3
Accession Number NM_003239
Gene ID 7043
Species Human
Product Type Lentivirus plasmid (overexpression)
Insert Length 1239 bp
Gene Alias ARVD,ARVD1,LDS5,RNHF,TGF-beta3
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin

Reference




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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T22978-Ab Anti-TGFB3/ ARVD/ ARVD1 monoclonal antibody
    Target Antigen GM-Tg-g-T22978-Ag TGFB3 VLP (virus-like particle)
    Cytokine cks-Tg-g-GM-T22978 transforming growth factor, beta 3 (TGFB3) protein & antibody
    ORF Viral Vector pGMLP003661 Human TGFB3 Lentivirus plasmid
    ORF Viral Vector pGMLP-SPh-039 Human TGFB3 Lentivirus plasmid
    ORF Viral Vector pGMAP-SPh-179 Human TGFB3 Adenovirus plasmid
    ORF Viral Vector vGMLP003661 Human TGFB3 Lentivirus particle
    ORF Viral Vector vGMLP-SPh-039 Human TGFB3 Lentivirus particle
    ORF Viral Vector vGMAP-SPh-179 Human TGFB3 Adenovirus particle


    Target information

    Target ID GM-T22978
    Target Name TGFB3
    Gene ID 7043, 21809, 703239, 25717, 101098469, 490796, 538957, 100051765
    Gene Symbol and Synonyms ARVD,ARVD1,LDS5,RNHF,TGF-B3,TGF-beta-3,TGF-beta3,Tgfb-3,TGFB3,TGFbeta3
    Uniprot Accession P10600
    Uniprot Entry Name TGFB3_HUMAN
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target, Cytokine Target
    Disease Breast Cancer
    Gene Ensembl ENSG00000119699
    Target Classification Checkpoint-Immuno Oncology

    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016]



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