Human RDH12/LCA13/RP53 ORF/cDNA clone-Adeno-associate virus(AAV) plasmid (NM_152443.2)

Cat. No.: pGMAAV001533
Size: 10 µg
Concentration: generally 0.5ug/ul, usually not less than 0.3ug/ul
Leading Time: 3-7 working days

Pre-made Human RDH12/LCA13/RP53 Adeno-associated virus expression plasmid (ITR-vector) for RDH12 AAV packaging, RDH12 AAV production.The purified Human RDH12/LCA13/RP53 AAV particle serves as an invaluable asset for in-depth in vivo RDH12 studies, mechanism of action (MOA) research, and the evolution of RDH12-associated gene therapy strategies.

Our GM-AAV ITR vector is optimized with the G-NEXT™ multi-serotypes AAV vector system. Explore the G-NEXT™ system in detail.

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Product Description

Catalog ID pGMAAV001533
Gene Name RDH12
Accession Number NM_152443.2
Gene ID 145226
Species Human
Product Type Adeno-associate virus(AAV) plasmid (overexpression)
Insert Length 951 bp
Gene Alias LCA13,RP53,SDR7C2
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Null
Fusion Tag 1xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence ATGCTGGTCACCTTGGGACTGCTCACCTCCTTCTTCTCGTTCCTGTATATGGTAGCTCCATCCATCAGGAAGTTCTTTGCTGGTGGAGTGTGTAGAACAAATGTGCAGCTTCCTGGCAAGGTAGTGGTGATCACTGGCGCCAACACGGGCATTGGCAAGGAGACGGCCAGAGAGCTCGCTAGCCGAGGAGCCCGAGTCTATATTGCCTGCAGAGATGTACTGAAGGGGGAGTCTGCTGCCAGTGAAATCCGAGTGGATACAAAGAACTCCCAGGTGCTGGTGCGGAAATTGGACCTATCCGACACCAAATCTATCCGAGCCTTTGCTGAGGGCTTTCTGGCAGAGGAAAAGCAGCTCCATATTCTGATCAACAATGCGGGAGTAATGATGTGTCCATATTCCAAGACAGCTGATGGCTTTGAAACCCACCTGGGAGTCAACCACCTGGGCCACTTCCTCCTCACCTACCTGCTCCTGGAGCGGCTAAAGGTGTCTGCCCCTGCACGGGTGGTTAATGTGTCCTCGGTGGCTCACCACATTGGCAAGATTCCCTTCCACGACCTCCAGAGCGAGAAGCGCTACAGCAGGGGTTTTGCCTATTGCCACAGCAAGCTGGCCAATGTGCTTTTTACTCGTGAGCTGGCCAAGAGGCTCCAAGGCACCGGGGTCACCACCTACGCAGTGCACCCAGGCGTCGTCCGCTCTGAGCTGGTCCGGCACTCCTCCCTGCTCTGCCTGCTCTGGCGGCTCTTCTCCCCCTTTGTCAAGACGGCACGGGAGGGGGCGCAGACCAGCCTGCACTGCGCCCTGGCTGAGGGCCTGGAGCCCCTGAGTGGCAAGTACTTCAGTGACTGCAAGAGGACCTGGGTGTCTCCAAGGGCCCGAAATAACAAAACAGCTGAGCGCCTATGGAATGTCAGCTGTGAGCTTCTAGGAATCCGGTGGGAGTAG
ORF Protein Sequence MLVTLGLLTSFFSFLYMVAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGESAASEIRVDTKNSQVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILINNAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIPFHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLLCLLWRLFSPFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTAERLWNVSCELLGIRWE

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-SE1513-Ab Anti-RDH12/ LCA13/ RP53 functional antibody
    Target Antigen GM-Tg-g-SE1513-Ag RDH12 protein
    ORF Viral Vector pGMLP003533 Human RDH12 Lentivirus plasmid
    ORF Viral Vector pGMLP003880 Human RDH12 Lentivirus plasmid
    ORF Viral Vector pGMAAV001533 Human RDH12 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector pGMAAV001534 Human RDH12 Adeno-associate virus(AAV) plasmid
    ORF Viral Vector vGMLP003533 Human RDH12 Lentivirus particle
    ORF Viral Vector vGMLP003880 Human RDH12 Lentivirus particle
    ORF Viral Vector vGMAAV001533 Human RDH12 Adeno-associate virus(AAV) particle
    ORF Viral Vector vGMAAV001534 Human RDH12 Adeno-associate virus(AAV) particle


    Target information

    Target ID GM-SE1513
    Target Name RDH12
    Gene ID 145226, 77974, 711438, 314264, 101093615, 490744, 369021, 100063369
    Gene Symbol and Synonyms DSSDR2,LCA13,RDH12,RP53,SDR7C2
    Uniprot Accession Q96NR8
    Uniprot Entry Name RDH12_HUMAN
    Protein Sub-location Secreted Protein/Potential Cytokines
    Category Not Available
    Disease Not Available
    Gene Ensembl ENSG00000139988
    Target Classification Not Available

    The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 13 and Retinitis Pigmentosa 53. [provided by RefSeq, Sep 2015]



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