CLU: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of CLU. The page also collects GeneMedi's different modalities and formats products for CLU in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CLU target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011]
Target ID | GM-T96669 |
Target Name | CLU |
Gene ID | 1191,12759,24854,677866,442971,101092846,280750,100034172 |
Gene Symbol and Synonyms | AAG4,APO-J,APOJ,CLI,CLU,CLU1,CLU2,D14Ucla3,DAG,GP80,gpIII,KUB1,NA1/NA2,RATTRPM2B,SGP-2,SGP2,SP-40,SP40,Sugp-2,TRPM-2,TRPM2,TRPM2B,Trpmb |
Uniprot Accession | P10909,P05371,P25473,P17697,Q29482 |
Uniprot Entry Name | CLUS_HUMAN,CLUS_RAT,CLUS_CANLF,CLUS_BOVIN,CLUS_HORSE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Therapeutics Target, INN Index |
Disease | leukemia patients, Acute kidney failure, Dent disease, Type 2 diabetes mellitus |
Gene Ensembl | ENSG00000120885 |
Target Classification | N/A |
Pre-made CLU-specific INN-index biosimilar (antibody&conjugates)
Anti-CLU therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Cat No. | Products Name (INN Index) | INN Name | Previous Name | Target | Format | Detail |
GMP-Bios-ab-696 | Pre-Made Sotevtamab biosimilar, Whole mAb, Anti-CLU/Clusterinm Antibody: Anti-AAG4/APO-J/APOJ/CLI/KUB1/NA1/NA2/SGP-2/SGP2/SP-40/TRPM-2/TRPM2 therapeutic antibody | Sotevtamab | CLU/Clusterin | Whole mAb | Detail |
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-CLU inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-CLU benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CLU mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-CLU monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Recombinant multi-species CLUS/ CLU/ AAG4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CLU protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
CLU protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made CLU viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMAD000502 | human CLU Adenovirus particle | NM_001831.3 | Human | Adenovirus particle | Detail |
vGMLV000313 | human CLU Lentivirus particle | NM_001831.3 | Human | Lentivirus particle | Detail |
pGMLV000313 | human CLU Lentivirus plasmid | NM_001831.3 | Human | Lentivirus plasmid | Detail |
vGMAD000637 | human CLU Adenovirus particle | NM_001831.3 | Human | Adenovirus particle | Detail |
pGMAD000502 | human CLU Adenovirus plasmid | NM_001831.3 | Human | Adenovirus plasmid | Detail |
pGMAD000637 | human CLU Adenovirus plasmid | NM_001831.3 | Human | Adenovirus plasmid | Detail |
pGMAAV000344 | Norway rat Clu AAV plasmid | NM_053021.2 | Norway Rat | AAV plasmid | Detail |
pGMAAV000345 | house mouse Clu AAV plasmid | NM_013492.3 | House Mouse | AAV plasmid | Detail |
pGMLPm004458 | mouse Clu Lentivirus plasmid | NM_013492 | Mouse | Lentivirus plasmid | Detail |
vGMAAV000344 | Norway rat Clu AAV particle | NM_053021.2 | Norway Rat | AAV particle | Detail |
vGMAAV000345 | house mouse Clu AAV particle | NM_013492.3 | House Mouse | AAV particle | Detail |
vGMLPm004458 | mouse Clu Lentivirus particle | NM_013492 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.