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Anti-CLUS/ CLU/ AAG4 functional antibody
Anti-CLUS/ CLU/ AAG4 functional antibody for cell culture, ELISA & in-vivo assay
Go to CLU/CLU products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T96669-Ab-1/ GM-Tg-hg-T96669-Ab-2 | Anti-Human CLU monoclonal antibody | Human |
| GM-Tg-rg-T96669-Ab-1/ GM-Tg-rg-T96669-Ab-2 | Anti-Rat CLU monoclonal antibody | Rat |
| GM-Tg-mg-T96669-Ab-1/ GM-Tg-mg-T96669-Ab-2 | Anti-Mouse CLU monoclonal antibody | Mouse |
| GM-Tg-cynog-T96669-Ab-1/ GM-Tg-cynog-T96669-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CLU monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T96669-Ab-1/ GM-Tg-felg-T96669-Ab-2 | Anti-Feline CLU monoclonal antibody | Feline |
| GM-Tg-cang-T96669-Ab-1/ GM-Tg-cang-T96669-Ab-2 | Anti-Canine CLU monoclonal antibody | Canine |
| GM-Tg-bovg-T96669-Ab-1/ GM-Tg-bovg-T96669-Ab-2 | Anti-Bovine CLU monoclonal antibody | Bovine |
| GM-Tg-equg-T96669-Ab-1/ GM-Tg-equg-T96669-Ab-2 | Anti-Equine CLU monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T96669-Ab-1/ GM-Tg-hg-T96669-Ab-2; GM-Tg-rg-T96669-Ab-1/ GM-Tg-rg-T96669-Ab-2; GM-Tg-mg-T96669-Ab-1/ GM-Tg-mg-T96669-Ab-2; GM-Tg-cynog-T96669-Ab-1/ GM-Tg-cynog-T96669-Ab-2; GM-Tg-felg-T96669-Ab-1/ GM-Tg-felg-T96669-Ab-2; GM-Tg-cang-T96669-Ab-1/ GM-Tg-cang-T96669-Ab-2; GM-Tg-bovg-T96669-Ab-1/ GM-Tg-bovg-T96669-Ab-2; GM-Tg-equg-T96669-Ab-1/ GM-Tg-equg-T96669-Ab-2 |
| Products Name | Anti-CLU monoclonal antibody |
| Format | mab |
| Target Name | CLU |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CLU benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-696 | Pre-Made Sotevtamab biosimilar, Whole mAb, Anti-CLU/Clusterinm Antibody: Anti-AAG4/APO-J/APOJ/CLI/KUB1/NA1/NA2/SGP-2/SGP2/SP-40/TRPM-2/TRPM2 therapeutic antibody |
| Target Antigen | GM-Tg-g-T96669-Ag-1 | Recombinant multi-species CLUS/ CLU/ AAG4 protein |
| ORF Viral Vector | vGMAD000502 | human CLU Adenovirus particle |
| ORF Viral Vector | vGMLV000313 | human CLU Lentivirus particle |
| ORF Viral Vector | pGMLV000313 | human CLU Lentivirus plasmid |
| ORF Viral Vector | vGMAD000637 | human CLU Adenovirus particle |
| ORF Viral Vector | pGMAD000502 | human CLU Adenovirus plasmid |
| ORF Viral Vector | pGMAD000637 | human CLU Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000344 | Norway rat Clu AAV plasmid |
| ORF Viral Vector | pGMAAV000345 | house mouse Clu AAV plasmid |
| ORF Viral Vector | pGMLPm004458 | mouse Clu Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000344 | Norway rat Clu AAV particle |
| ORF Viral Vector | vGMAAV000345 | house mouse Clu AAV particle |
| ORF Viral Vector | vGMLPm004458 | mouse Clu Lentivirus particle |
Target information
| Target ID | GM-T96669 |
| Target Name | CLU |
| Gene ID | 1191,12759,24854,677866,442971,101092846,280750,100034172 |
| Gene Symbol and Synonyms | AAG4,APO-J,APOJ,CLI,CLU,CLU1,CLU2,D14Ucla3,DAG,GP80,gpIII,KUB1,NA1/NA2,RATTRPM2B,SGP-2,SGP2,SP-40,SP40,Sugp-2,TRPM-2,TRPM2,TRPM2B,Trpmb |
| Uniprot Accession | P10909,P05371,P25473,P17697,Q29482 |
| Uniprot Entry Name | CLUS_HUMAN,CLUS_RAT,CLUS_CANLF,CLUS_BOVIN,CLUS_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | leukemia patients, Acute kidney failure, Dent disease, Type 2 diabetes mellitus |
| Gene Ensembl | ENSG00000120885 |
| Target Classification | N/A |
The target: CLU, gene name: CLU, also named as AAG4, APO-J, APOJ, CLI1, CLU2, KUB1, NA1/NA2, SGP-2, SGP2, SP-40, TRPM-2, TRPM2, CLU. The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.[provided by RefSeq, May 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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