CTNNB1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of CTNNB1. The page also collects GeneMedi's different modalities and formats products for CTNNB1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CTNNB1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Target ID | GM-T82795 |
Target Name | CTNNB1 |
Gene ID | 1499,12387,84353,574265,477032,101097342,539003,100055241 |
Gene Symbol and Synonyms | armadillo,Bfc,Catnb,CTNNB,CTNNB1,EVR7,Jup,Mesc,MRD19,NEDSDV |
Uniprot Accession | P35222,Q9WU82,B6V8E6,Q0VCX4 |
Uniprot Entry Name | CTNB1_HUMAN,CTNB1_RAT,CTNB1_CANLF,CTNB1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target |
Disease | breast cancer |
Gene Ensembl | ENSG00000168036 |
Target Classification | Checkpoint-Immuno Oncology, Pathway |
Pre-made anti-CTNNB1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-CTNNB1 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CTNNB1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-CTNNB1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species CTNB1/ CTNNB1/ CTNNB VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CTNNB1 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
CTNNB1 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made CTNNB1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMAD000646 | human CTNNB1 Adenovirus plasmid | NM_001904 | Human | Adenovirus plasmid | Detail |
pGMLV000559 | human CTNNB1-mu Lentivirus plasmid | NM_001098209.1 | Human | Lentivirus plasmid | Detail |
vGMLP002747 | human CTNNB1 Lentivirus particle | NM_001904 | Human | Lentivirus particle | Detail |
vGMLV000559 | human CTNNB1-mu Lentivirus particle | NM_001098209.1 | Human | Lentivirus particle | Detail |
vGMAD000131 | human CTNNB1 Adenovirus particle | NM_001904.3 | Human | Adenovirus particle | Detail |
pGMAD000131 | human CTNNB1 Adenovirus plasmid | NM_001904.3 | Human | Adenovirus plasmid | Detail |
pGMAD000591 | human CTNNB1 Adenovirus plasmid | NM_001904.1 | Human | Adenovirus plasmid | Detail |
vGMAD000591 | human CTNNB1 Adenovirus particle | NM_001904.1 | Human | Adenovirus particle | Detail |
pGMLP002747 | human CTNNB1 Lentivirus plasmid | NM_001904 | Human | Lentivirus plasmid | Detail |
vGMAD000646 | human CTNNB1 Adenovirus particle | NM_001904 | Human | Adenovirus particle | Detail |
pGMLV000041 | rat Ctnnb1 Lentivirus plasmid | NM_053357.2 | Rat | Lentivirus plasmid | Detail |
pGMLV000375 | mouse Ctnnb1 Lentivirus plasmid | NM_001165902.1 | Mouse | Lentivirus plasmid | Detail |
pGMLV000551 | Norway rat Ctnnb1 Lentivirus plasmid | NM_053357.2 | Norway Rat | Lentivirus plasmid | Detail |
pGMAD000596 | house mouse Ctnnb1 Adenovirus plasmid | NM_001165902.1 | House Mouse | Adenovirus plasmid | Detail |
vGMLV000041 | rat Ctnnb1 Lentivirus particle | NM_053357.2 | Rat | Lentivirus particle | Detail |
vGMLV000375 | mouse Ctnnb1 Lentivirus particle | NM_001165902.1 | Mouse | Lentivirus particle | Detail |
vGMLV000551 | Norway rat Ctnnb1 Lentivirus particle | NM_053357.2 | Norway Rat | Lentivirus particle | Detail |
vGMAD000596 | house mouse Ctnnb1 Adenovirus particle | NM_001165902.1 | House Mouse | Adenovirus particle | Detail |
About Promise-ORFTM:
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