Anti-CTNB1/ CTNNB1/ CTNNB monoclonal antibody

Anti-CTNB1/ CTNNB1/ CTNNB antibody for FACS & in-vivo assay

Target products collectionGo to CTNNB1/CTNNB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T82795-Ab-1/ GM-Tg-hg-T82795-Ab-2Anti-Human CTNNB1 monoclonal antibodyHuman
GM-Tg-rg-T82795-Ab-1/ GM-Tg-rg-T82795-Ab-2Anti-Rat CTNNB1 monoclonal antibodyRat
GM-Tg-mg-T82795-Ab-1/ GM-Tg-mg-T82795-Ab-2Anti-Mouse CTNNB1 monoclonal antibodyMouse
GM-Tg-cynog-T82795-Ab-1/ GM-Tg-cynog-T82795-Ab-2Anti-Cynomolgus/ Rhesus macaque CTNNB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T82795-Ab-1/ GM-Tg-felg-T82795-Ab-2Anti-Feline CTNNB1 monoclonal antibodyFeline
GM-Tg-cang-T82795-Ab-1/ GM-Tg-cang-T82795-Ab-2Anti-Canine CTNNB1 monoclonal antibodyCanine
GM-Tg-bovg-T82795-Ab-1/ GM-Tg-bovg-T82795-Ab-2Anti-Bovine CTNNB1 monoclonal antibodyBovine
GM-Tg-equg-T82795-Ab-1/ GM-Tg-equg-T82795-Ab-2Anti-Equine CTNNB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T82795-Ab-1/ GM-Tg-hg-T82795-Ab-2; GM-Tg-rg-T82795-Ab-1/ GM-Tg-rg-T82795-Ab-2;
GM-Tg-mg-T82795-Ab-1/ GM-Tg-mg-T82795-Ab-2; GM-Tg-cynog-T82795-Ab-1/ GM-Tg-cynog-T82795-Ab-2;
GM-Tg-felg-T82795-Ab-1/ GM-Tg-felg-T82795-Ab-2; GM-Tg-cang-T82795-Ab-1/ GM-Tg-cang-T82795-Ab-2;
GM-Tg-bovg-T82795-Ab-1/ GM-Tg-bovg-T82795-Ab-2; GM-Tg-equg-T82795-Ab-1/ GM-Tg-equg-T82795-Ab-2
Products NameAnti-CTNNB1 monoclonal antibody
Formatmab
Target NameCTNNB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CTNNB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CTNB1/ CTNNB1/ CTNNB VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAD000646human CTNNB1 Adenovirus plasmid
    ORF Viral VectorpGMLV000559human CTNNB1-mu Lentivirus plasmid
    ORF Viral VectorvGMLP002747human CTNNB1 Lentivirus particle
    ORF Viral VectorvGMLV000559human CTNNB1-mu Lentivirus particle
    ORF Viral VectorvGMAD000131human CTNNB1 Adenovirus particle
    ORF Viral VectorpGMAD000131human CTNNB1 Adenovirus plasmid
    ORF Viral VectorpGMAD000591human CTNNB1 Adenovirus plasmid
    ORF Viral VectorvGMAD000591human CTNNB1 Adenovirus particle
    ORF Viral VectorpGMLP002747human CTNNB1 Lentivirus plasmid
    ORF Viral VectorvGMAD000646human CTNNB1 Adenovirus particle
    ORF Viral VectorpGMLV000041rat Ctnnb1 Lentivirus plasmid
    ORF Viral VectorpGMLV000375mouse Ctnnb1 Lentivirus plasmid
    ORF Viral VectorpGMLV000551Norway rat Ctnnb1 Lentivirus plasmid
    ORF Viral VectorpGMAD000596house mouse Ctnnb1 Adenovirus plasmid
    ORF Viral VectorvGMLV000041rat Ctnnb1 Lentivirus particle
    ORF Viral VectorvGMLV000375mouse Ctnnb1 Lentivirus particle
    ORF Viral VectorvGMLV000551Norway rat Ctnnb1 Lentivirus particle
    ORF Viral VectorvGMAD000596house mouse Ctnnb1 Adenovirus particle


    Target information

    Target IDGM-T82795
    Target NameCTNNB1
    Gene ID1499,12387,84353,574265,477032,101097342,539003,100055241
    Gene Symbol and Synonymsarmadillo,Bfc,Catnb,CTNNB,CTNNB1,EVR7,Jup,Mesc,MRD19,NEDSDV
    Uniprot AccessionP35222,Q9WU82,B6V8E6,Q0VCX4
    Uniprot Entry NameCTNB1_HUMAN,CTNB1_RAT,CTNB1_CANLF,CTNB1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target
    Diseasebreast cancer
    Gene EnsemblENSG00000168036
    Target ClassificationCheckpoint-Immuno Oncology, Pathway

    The target: CTNNB1, gene name: CTNNB1, also named as CTNNB, EVR7, MRD19, armadillo. The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.