BMP2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of BMP2. The page also collects GeneMedi's different modalities and formats products for BMP2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the BMP2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Target ID | GM-T68383 |
Target Name | BMP2 |
Gene ID | 650,12156,29373,718330,477162,100301987,615037,100051701 |
Gene Symbol and Synonyms | BDA2,BMP2,BMP2A,SSFSC,SSFSC1 |
Uniprot Accession | P12643,P49001 |
Uniprot Entry Name | BMP2_HUMAN,BMP2_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Cytokine Target |
Disease | Cancer |
Gene Ensembl | ENSG00000125845 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-BMP2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-BMP2 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-BMP2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-BMP2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
Multi-species BMP2/ BDA2A/ SSFSC VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BMP2 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
BMP2 VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 2 (BMP2) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis., Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse bone morphogenetic protein 2a (BMP2A) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-?? superfamily of proteins. BMP-2 like other bone morphogenetic proteins, plays an important role in the development of bone and cartilage. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition.? Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types.?? BMP-2 may be involved in white adipogenesis and may have metabolic effects., Bone morphogenetic protein 2A (BMP2A), a member of the decapentaplegic-Vg-related family, belongs to the transforming growth factor beta superfamily and has a striking sequence similarity to the decapentaplegic locus in Drosophila melanogaster, a major determinant of pattern specification during embryogenesis. BMP2A is thought to be involved in cartilage and bone formation during embryogenesis, but may have additional functions in morphogenesis as implied by its expression in various organs and embryonic tissues of mice. Human BMP2A, assigned to chromosome 20 by the use of human-Chinese hamster ovary cell hybrids, is considered to be a reasonable candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. We have confirmed the localization of BMP2A to chromosome 20 and regionally assigned the locus to 20p12 by radioactive and nonradioactive in situ hybridization.
Target | Species | Antigen Product Name | Bioactivity validation of Antigen | Antibody Product Name | Bioactivity validation of Antibodies | Detail |
BMP2/BMP2a | Human, Cynomolgus/Rhesus macaque, rat, mouse | bone morphogenetic protein 2 (BMP2/BMP2a) protein | Affintiy&bioactivity validated by ELISA, cell culture validated | Anti-BMP2/BMP2a monoclonal antibody | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). | Detail |
Click to check more Cytokine Products
Pre-made BMP2 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLP002836 | human BMP2 Lentivirus plasmid | NM_001200 | Human | Lentivirus plasmid | Detail |
vGMLP002836 | human BMP2 Lentivirus particle | NM_001200 | Human | Lentivirus particle | Detail |
pGMAD000553 | human BMP2 Adenovirus plasmid | NM_001200.4 | Human | Adenovirus plasmid | Detail |
vGMAD000553 | human BMP2 Adenovirus particle | NM_001200.4 | Human | Adenovirus particle | Detail |
pGMLV000859 | house mouse Bmp2 Lentivirus plasmid | NM_007553.3 | House Mouse | Lentivirus plasmid | Detail |
pGMAD000286 | rat Bmp2 Adenovirus plasmid | NM_017178 | Rat | Adenovirus plasmid | Detail |
pGMLPm005137 | mouse Bmp2 Lentivirus plasmid | XM_006498619.1 | Mouse | Lentivirus plasmid | Detail |
vGMLV000859 | house mouse Bmp2 Lentivirus particle | NM_007553.3 | House Mouse | Lentivirus particle | Detail |
vGMAD000286 | rat Bmp2 Adenovirus particle | NM_017178 | Rat | Adenovirus particle | Detail |
vGMLPm005137 | mouse Bmp2 Lentivirus particle | XM_006498619.1 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
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