Anti-BMP2/ BDA2A/ SSFSC monoclonal antibody

Anti-BMP2/ BDA2A/ SSFSC antibody for FACS & in-vivo assay

Target products collectionGo to BMP2/BMP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T68383-Ab-1/ GM-Tg-hg-T68383-Ab-2Anti-Human BMP2 monoclonal antibodyHuman
GM-Tg-rg-T68383-Ab-1/ GM-Tg-rg-T68383-Ab-2Anti-Rat BMP2 monoclonal antibodyRat
GM-Tg-mg-T68383-Ab-1/ GM-Tg-mg-T68383-Ab-2Anti-Mouse BMP2 monoclonal antibodyMouse
GM-Tg-cynog-T68383-Ab-1/ GM-Tg-cynog-T68383-Ab-2Anti-Cynomolgus/ Rhesus macaque BMP2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T68383-Ab-1/ GM-Tg-felg-T68383-Ab-2Anti-Feline BMP2 monoclonal antibodyFeline
GM-Tg-cang-T68383-Ab-1/ GM-Tg-cang-T68383-Ab-2Anti-Canine BMP2 monoclonal antibodyCanine
GM-Tg-bovg-T68383-Ab-1/ GM-Tg-bovg-T68383-Ab-2Anti-Bovine BMP2 monoclonal antibodyBovine
GM-Tg-equg-T68383-Ab-1/ GM-Tg-equg-T68383-Ab-2Anti-Equine BMP2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T68383-Ab-1/ GM-Tg-hg-T68383-Ab-2; GM-Tg-rg-T68383-Ab-1/ GM-Tg-rg-T68383-Ab-2;
GM-Tg-mg-T68383-Ab-1/ GM-Tg-mg-T68383-Ab-2; GM-Tg-cynog-T68383-Ab-1/ GM-Tg-cynog-T68383-Ab-2;
GM-Tg-felg-T68383-Ab-1/ GM-Tg-felg-T68383-Ab-2; GM-Tg-cang-T68383-Ab-1/ GM-Tg-cang-T68383-Ab-2;
GM-Tg-bovg-T68383-Ab-1/ GM-Tg-bovg-T68383-Ab-2; GM-Tg-equg-T68383-Ab-1/ GM-Tg-equg-T68383-Ab-2
Products NameAnti-BMP2 monoclonal antibody
Formatmab
Target NameBMP2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-BMP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species BMP2/ BDA2A/ SSFSC VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T68383-Ag-1bone morphogenetic protein 2 (BMP2) protein
    ORF Viral VectorpGMLP002836human BMP2 Lentivirus plasmid
    ORF Viral VectorvGMLP002836human BMP2 Lentivirus particle
    ORF Viral VectorpGMAD000553human BMP2 Adenovirus plasmid
    ORF Viral VectorvGMAD000553human BMP2 Adenovirus particle
    ORF Viral VectorpGMLV000859house mouse Bmp2 Lentivirus plasmid
    ORF Viral VectorpGMAD000286rat Bmp2 Adenovirus plasmid
    ORF Viral VectorpGMLPm005137mouse Bmp2 Lentivirus plasmid
    ORF Viral VectorvGMLV000859house mouse Bmp2 Lentivirus particle
    ORF Viral VectorvGMAD000286rat Bmp2 Adenovirus particle
    ORF Viral VectorvGMLPm005137mouse Bmp2 Lentivirus particle


    Target information

    Target IDGM-T68383
    Target NameBMP2
    Gene ID650,12156,29373,718330,477162,100301987,615037,100051701
    Gene Symbol and SynonymsBDA2,BMP2,BMP2A,SSFSC,SSFSC1
    Uniprot AccessionP12643,P49001
    Uniprot Entry NameBMP2_HUMAN,BMP2_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000125845
    Target ClassificationTumor-associated antigen (TAA)

    The target: BMP2, gene name: BMP2, also named as BDA2A, SSFSC, BMP2. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.