TFRC: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of TFRC. The page also collects GeneMedi's different modalities and formats products for TFRC in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TFRC target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Transmembrane Protein.
This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
Target ID | GM-T33976 |
Target Name | TFRC |
Gene ID | 7037,22042,64678,711568,403703,493880,504698,100034089 |
Gene Symbol and Synonyms | 2610028K12Rik,CD71,E430033M20Rik,IMD46,Mtvr1,p90,T9,TFR,TFR1,TFRC,TR,TRFR |
Uniprot Accession | P02786,Q99376,Q9GLD3,Q9MYZ3,Q2V905 |
Uniprot Entry Name | TFR1_HUMAN,TFR1_RAT,TFR1_FELCA,TFR1_CANLF,TFR1_HORSE |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | Cancer |
Gene Ensembl | ENSG00000072274 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made TFRC-specific INN-index biosimilar (antibody&conjugates)
Anti-TFRC therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Cat No. | Products Name (INN Index) | INN Name | Previous Name | Target | Format | Detail |
GMP-Bios-ab-675 | Pre-Made Lepunafusp biosimilar, Whole mAb, Anti-TfR1/TFRC Antibody: Anti-CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 therapeutic antibody | Lepunafusp | TfR1/TFRC | Whole mAb Fusion | Detail | |
GMP-Bios-INN-888 | Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 | lepunafusp alfa | TFRC | Fusion Protein | Detail | |
GMP-Bios-INN-943 | Pre-Made Pabinafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with iduronate-2-sulfatase: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 | pabinafusp alfa | TFRC | Fusion Protein | Detail | |
GMP-Bios-ab-420 | Pre-Made Pabinafusp biosimilar, Whole mAb Fusion, Anti-TFRC Antibody: Anti-CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 therapeutic antibody | Pabinafusp | TFRC | Whole mAb Fusion | Detail |
Click to check more INN-indexed antibody & protein biosimilar
Pre-made anti-TFRC inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-TFRC benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TFRC mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-TFRC monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Multi-species TFR1/ TFRC/ CD71 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TFRC VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
TFRC VLP (virus-like particle) | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Products Developing |
Pre-made TFRC viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
vGMLV000258 | human TFRC Lentivirus particle | NM_003234.3 | Human | Lentivirus particle | Detail |
pGMLV000258 | human TFRC Lentivirus plasmid | NM_003234.3 | Human | Lentivirus plasmid | Detail |
vGMLV000504 | human TFRC Lentivirus particle | NM_003234.3 | Human | Lentivirus particle | Detail |
pGMLV000504 | human TFRC Lentivirus plasmid | NM_003234.3 | Human | Lentivirus plasmid | Detail |
pGMLPm004095 | mouse Tfrc Lentivirus plasmid | NM_011638 | Mouse | Lentivirus plasmid | Detail |
vGMLPm004095 | mouse Tfrc Lentivirus particle | NM_011638 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.