TFRC: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of TFRC. The page also collects GeneMedi's different modalities and formats products for TFRC in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the TFRC target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Transmembrane Protein.

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Target IDGM-T33976
Target NameTFRC
Gene ID7037,22042,64678,711568,403703,493880,504698,100034089
Gene Symbol and Synonyms2610028K12Rik,CD71,E430033M20Rik,IMD46,Mtvr1,p90,T9,TFR,TFR1,TFRC,TR,TRFR
Uniprot AccessionP02786,Q99376,Q9GLD3,Q9MYZ3,Q2V905
Uniprot Entry NameTFR1_HUMAN,TFR1_RAT,TFR1_FELCA,TFR1_CANLF,TFR1_HORSE
Protein Sub-locationTransmembrane Protein
CategoryTherapeutics Target, INN Index
DiseaseCancer
Gene EnsemblENSG00000072274
Target ClassificationTumor-associated antigen (TAA)


Pre-made TFRC-specific INN-index biosimilar (antibody&conjugates)

Anti-TFRC therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.Products Name (INN Index)INN Name Previous Name Target FormatDetail
GMP-Bios-ab-675Pre-Made Lepunafusp biosimilar, Whole mAb, Anti-TfR1/TFRC Antibody: Anti-CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 therapeutic antibodyLepunafuspTfR1/TFRCWhole mAb FusionDetail
GMP-Bios-INN-888Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90lepunafusp alfaTFRCFusion ProteinDetail
GMP-Bios-INN-943Pre-Made Pabinafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with iduronate-2-sulfatase: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90pabinafusp alfaTFRCFusion ProteinDetail
GMP-Bios-ab-420Pre-Made Pabinafusp biosimilar, Whole mAb Fusion, Anti-TFRC Antibody: Anti-CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 therapeutic antibodyPabinafuspTFRCWhole mAb FusionDetail

Click to check more INN-indexed antibody & protein biosimilar



Pre-made anti-TFRC inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-TFRC benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-TFRC mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody NameSpeciesFormatClassified by tagDetail
Anti-TFRC monoclonal antibodyHuman, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquinemabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail



Multi-species TFR1/ TFRC/ CD71 VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TFRC VLP (virus-like particle) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products NameSpeciesExpression PlatformDetail
TFRC VLP (virus-like particle)Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, EquineMammalian cellProducts Developing



Pre-made TFRC viral vector in GM Promise-ORFTM

Cat No.Products nameNM IDSpeciesTypeDetail
vGMLV000258human TFRC Lentivirus particleNM_003234.3HumanLentivirus particleDetail
pGMLV000258human TFRC Lentivirus plasmidNM_003234.3HumanLentivirus plasmidDetail
vGMLV000504human TFRC Lentivirus particleNM_003234.3HumanLentivirus particleDetail
pGMLV000504human TFRC Lentivirus plasmidNM_003234.3HumanLentivirus plasmidDetail
pGMLPm004095mouse Tfrc Lentivirus plasmidNM_011638MouseLentivirus plasmidDetail
vGMLPm004095mouse Tfrc Lentivirus particleNM_011638MouseLentivirus particleDetail

About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.






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