Anti-TFR1/ TFRC/ CD71 monoclonal antibody
Anti-TFR1/ TFRC/ CD71 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T33976-Ab-1/ GM-Tg-hg-T33976-Ab-2 | Anti-Human TFRC monoclonal antibody | Human |
GM-Tg-rg-T33976-Ab-1/ GM-Tg-rg-T33976-Ab-2 | Anti-Rat TFRC monoclonal antibody | Rat |
GM-Tg-mg-T33976-Ab-1/ GM-Tg-mg-T33976-Ab-2 | Anti-Mouse TFRC monoclonal antibody | Mouse |
GM-Tg-cynog-T33976-Ab-1/ GM-Tg-cynog-T33976-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TFRC monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T33976-Ab-1/ GM-Tg-felg-T33976-Ab-2 | Anti-Feline TFRC monoclonal antibody | Feline |
GM-Tg-cang-T33976-Ab-1/ GM-Tg-cang-T33976-Ab-2 | Anti-Canine TFRC monoclonal antibody | Canine |
GM-Tg-bovg-T33976-Ab-1/ GM-Tg-bovg-T33976-Ab-2 | Anti-Bovine TFRC monoclonal antibody | Bovine |
GM-Tg-equg-T33976-Ab-1/ GM-Tg-equg-T33976-Ab-2 | Anti-Equine TFRC monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T33976-Ab-1/ GM-Tg-hg-T33976-Ab-2; GM-Tg-rg-T33976-Ab-1/ GM-Tg-rg-T33976-Ab-2; GM-Tg-mg-T33976-Ab-1/ GM-Tg-mg-T33976-Ab-2; GM-Tg-cynog-T33976-Ab-1/ GM-Tg-cynog-T33976-Ab-2; GM-Tg-felg-T33976-Ab-1/ GM-Tg-felg-T33976-Ab-2; GM-Tg-cang-T33976-Ab-1/ GM-Tg-cang-T33976-Ab-2; GM-Tg-bovg-T33976-Ab-1/ GM-Tg-bovg-T33976-Ab-2; GM-Tg-equg-T33976-Ab-1/ GM-Tg-equg-T33976-Ab-2 |
Products Name | Anti-TFRC monoclonal antibody |
Format | mab |
Target Name | TFRC |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-TFRC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Target information
Target ID | GM-T33976 |
Target Name | TFRC |
Gene ID | 7037,22042,64678,711568,403703,493880,504698,100034089 |
Gene Symbol and Synonyms | 2610028K12Rik,CD71,E430033M20Rik,IMD46,Mtvr1,p90,T9,TFR,TFR1,TFRC,TR,TRFR |
Uniprot Accession | P02786,Q99376,Q9GLD3,Q9MYZ3,Q2V905 |
Uniprot Entry Name | TFR1_HUMAN,TFR1_RAT,TFR1_FELCA,TFR1_CANLF,TFR1_HORSE |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, INN Index |
Disease | Cancer |
Gene Ensembl | ENSG00000072274 |
Target Classification | Tumor-associated antigen (TAA) |
The target: TFRC, gene name: TFRC, also named as CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.