Anti-TFR1/ TFRC/ CD71 monoclonal antibody

Anti-TFR1/ TFRC/ CD71 antibody for FACS & in-vivo assay

Target products collectionGo to TFRC/TFRC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T33976-Ab-1/ GM-Tg-hg-T33976-Ab-2Anti-Human TFRC monoclonal antibodyHuman
GM-Tg-rg-T33976-Ab-1/ GM-Tg-rg-T33976-Ab-2Anti-Rat TFRC monoclonal antibodyRat
GM-Tg-mg-T33976-Ab-1/ GM-Tg-mg-T33976-Ab-2Anti-Mouse TFRC monoclonal antibodyMouse
GM-Tg-cynog-T33976-Ab-1/ GM-Tg-cynog-T33976-Ab-2Anti-Cynomolgus/ Rhesus macaque TFRC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T33976-Ab-1/ GM-Tg-felg-T33976-Ab-2Anti-Feline TFRC monoclonal antibodyFeline
GM-Tg-cang-T33976-Ab-1/ GM-Tg-cang-T33976-Ab-2Anti-Canine TFRC monoclonal antibodyCanine
GM-Tg-bovg-T33976-Ab-1/ GM-Tg-bovg-T33976-Ab-2Anti-Bovine TFRC monoclonal antibodyBovine
GM-Tg-equg-T33976-Ab-1/ GM-Tg-equg-T33976-Ab-2Anti-Equine TFRC monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T33976-Ab-1/ GM-Tg-hg-T33976-Ab-2; GM-Tg-rg-T33976-Ab-1/ GM-Tg-rg-T33976-Ab-2;
GM-Tg-mg-T33976-Ab-1/ GM-Tg-mg-T33976-Ab-2; GM-Tg-cynog-T33976-Ab-1/ GM-Tg-cynog-T33976-Ab-2;
GM-Tg-felg-T33976-Ab-1/ GM-Tg-felg-T33976-Ab-2; GM-Tg-cang-T33976-Ab-1/ GM-Tg-cang-T33976-Ab-2;
GM-Tg-bovg-T33976-Ab-1/ GM-Tg-bovg-T33976-Ab-2; GM-Tg-equg-T33976-Ab-1/ GM-Tg-equg-T33976-Ab-2
Products NameAnti-TFRC monoclonal antibody
Formatmab
Target NameTFRC
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TFRC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-675Pre-Made Lepunafusp biosimilar, Whole mAb, Anti-TfR1/TFRC Antibody: Anti-CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 therapeutic antibody
    BiosimilarGMP-Bios-INN-888Pre-Made Lepunafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with human IDUA (iduronidase, alpha-L-) isoform 1 via a peptidyl linker: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90
    BiosimilarGMP-Bios-INN-943Pre-Made Pabinafusp Alfa Biosimilar, Fusion Protein targeting TFRC fused with iduronate-2-sulfatase: Recombinant therapeutic protein targeting CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90
    BiosimilarGMP-Bios-ab-420Pre-Made Pabinafusp biosimilar, Whole mAb Fusion, Anti-TFRC Antibody: Anti-CD71/IMD46/T9/TFR/TFR1/TR/TRFR/p90 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species TFR1/ TFRC/ CD71 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000258human TFRC Lentivirus particle
    ORF Viral VectorpGMLV000258human TFRC Lentivirus plasmid
    ORF Viral VectorvGMLV000504human TFRC Lentivirus particle
    ORF Viral VectorpGMLV000504human TFRC Lentivirus plasmid
    ORF Viral VectorpGMLPm004095mouse Tfrc Lentivirus plasmid
    ORF Viral VectorvGMLPm004095mouse Tfrc Lentivirus particle


    Target information

    Target IDGM-T33976
    Target NameTFRC
    Gene ID7037,22042,64678,711568,403703,493880,504698,100034089
    Gene Symbol and Synonyms2610028K12Rik,CD71,E430033M20Rik,IMD46,Mtvr1,p90,T9,TFR,TFR1,TFRC,TR,TRFR
    Uniprot AccessionP02786,Q99376,Q9GLD3,Q9MYZ3,Q2V905
    Uniprot Entry NameTFR1_HUMAN,TFR1_RAT,TFR1_FELCA,TFR1_CANLF,TFR1_HORSE
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000072274
    Target ClassificationTumor-associated antigen (TAA)

    The target: TFRC, gene name: TFRC, also named as CD71, IMD46, T9, TFR, TFR1, TR, TRFR, p90. This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.