SIRT1: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of SIRT1. The page also collects GeneMedi's different modalities and formats products for SIRT1 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the SIRT1 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Introcelluar Protein.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Target ID | GM-T14731 |
Target Name | SIRT1 |
Gene ID | 23411,93759,309757,695682,489012,101087610,613629,100072571 |
Gene Symbol and Synonyms | SIR2,Sir2a,SIR2alpha,SIR2L1,SIRT1,sirtuin-1 |
Uniprot Accession | Q96EB6,A0A0G2JZ79 |
Uniprot Entry Name | SIR1_HUMAN,SIR1_RAT |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000096717 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-SIRT1 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-SIRT1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-SIRT1 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-SIRT1 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | Therapeutics Target antibody | Detail |
Recombinant multi-species SIR1/ SIRT1/ SIR2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SIRT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
SIRT1 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Pre-made SIRT1 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMAD000463 | human SIRT1 Adenovirus plasmid | NM_012238.4 | Human | Adenovirus plasmid | Detail |
pGMLV000525 | human SIRT1 Lentivirus plasmid | NM_012238.4 | Human | Lentivirus plasmid | Detail |
vGMAD000463 | human SIRT1 Adenovirus particle | NM_012238.4 | Human | Adenovirus particle | Detail |
pGMLV000135 | human SIRT1 Lentivirus plasmid | NM_012238.4 | Human | Lentivirus plasmid | Detail |
vGMAD000579 | human SIRT1 Adenovirus particle | NM_012238.4 | Human | Adenovirus particle | Detail |
pGMAD000579 | human SIRT1 Adenovirus plasmid | NM_012238.4 | Human | Adenovirus plasmid | Detail |
vGMLV000135 | human SIRT1 Lentivirus particle | NM_012238.4 | Human | Lentivirus particle | Detail |
vGMAP000577 | Human SIRT1 Adenovirus particle | NM_012238 | Human | Adenovirus particle | Detail |
pGMAP000577 | Human SIRT1 Adenovirus plasmid | NM_012238 | Human | Adenovirus plasmid | Detail |
vGMLV000525 | human SIRT1 Lentivirus particle | NM_012238.4 | Human | Lentivirus particle | Detail |
pGMLV000090 | mouse Sirt1 Lentivirus plasmid | NM_019812.3 | Mouse | Lentivirus plasmid | Detail |
pGMLV000581 | house mouse Sirt1 Lentivirus plasmid | NM_019812.3 | House Mouse | Lentivirus plasmid | Detail |
pGMLV000831 | house mouse Sirt1 Lentivirus plasmid | NM_019812.3 | House Mouse | Lentivirus plasmid | Detail |
pGMAD000091 | cattle SIRT1 Adenovirus plasmid | NM_001192980 | Cattle | Adenovirus plasmid | Detail |
pGMAD000529 | Norway rat Sirt1 Adenovirus plasmid | XM_017601789 | Norway Rat | Adenovirus plasmid | Detail |
pGMAD000537 | house mouse Sirt1 Adenovirus plasmid | NM_019812 | House Mouse | Adenovirus plasmid | Detail |
pGMAD000630 | house mouse Sirt1 Adenovirus plasmid | NM_019812.3 | House Mouse | Adenovirus plasmid | Detail |
pGMAAV000201 | Norway rat Sirt1 AAV plasmid | XM_017601788.1 | Norway Rat | AAV plasmid | Detail |
vGMLV000090 | mouse Sirt1 Lentivirus particle | NM_019812.3 | Mouse | Lentivirus particle | Detail |
vGMLV000581 | house mouse Sirt1 Lentivirus particle | NM_019812.3 | House Mouse | Lentivirus particle | Detail |
vGMLV000831 | house mouse Sirt1 Lentivirus particle | NM_019812.3 | House Mouse | Lentivirus particle | Detail |
vGMAD000091 | cattle SIRT1 Adenovirus particle | NM_001192980 | Cattle | Adenovirus particle | Detail |
vGMAD000529 | Norway rat Sirt1 Adenovirus particle | XM_017601789 | Norway Rat | Adenovirus particle | Detail |
vGMAD000537 | house mouse Sirt1 Adenovirus particle | NM_019812 | House Mouse | Adenovirus particle | Detail |
vGMAD000630 | house mouse Sirt1 Adenovirus particle | NM_019812.3 | House Mouse | Adenovirus particle | Detail |
vGMAAV000201 | Norway rat Sirt1 AAV particle | XM_017601788.1 | Norway Rat | AAV particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.