Anti-SIRT1 monoclonal antibody

Pre-made anti-SIRT1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to SIRT1/SIRT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T14731-Ab-1/ GM-Tg-hg-T14731-Ab-2Anti-Human SIRT1 monoclonal antibodyHuman
GM-Tg-rg-T14731-Ab-1/ GM-Tg-rg-T14731-Ab-2Anti-Rat SIRT1 monoclonal antibodyRat
GM-Tg-mg-T14731-Ab-1/ GM-Tg-mg-T14731-Ab-2Anti-Mouse SIRT1 monoclonal antibodyMouse
GM-Tg-cynog-T14731-Ab-1/ GM-Tg-cynog-T14731-Ab-2Anti-Cynomolgus/ Rhesus macaque SIRT1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T14731-Ab-1/ GM-Tg-felg-T14731-Ab-2Anti-Feline SIRT1 monoclonal antibodyFeline
GM-Tg-cang-T14731-Ab-1/ GM-Tg-cang-T14731-Ab-2Anti-Canine SIRT1 monoclonal antibodyCanine
GM-Tg-bovg-T14731-Ab-1/ GM-Tg-bovg-T14731-Ab-2Anti-Bovine SIRT1 monoclonal antibodyBovine
GM-Tg-equg-T14731-Ab-1/ GM-Tg-equg-T14731-Ab-2Anti-Equine SIRT1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T14731-Ab-1/ GM-Tg-hg-T14731-Ab-2; GM-Tg-rg-T14731-Ab-1/ GM-Tg-rg-T14731-Ab-2;
GM-Tg-mg-T14731-Ab-1/ GM-Tg-mg-T14731-Ab-2; GM-Tg-cynog-T14731-Ab-1/ GM-Tg-cynog-T14731-Ab-2;
GM-Tg-felg-T14731-Ab-1/ GM-Tg-felg-T14731-Ab-2; GM-Tg-cang-T14731-Ab-1/ GM-Tg-cang-T14731-Ab-2;
GM-Tg-bovg-T14731-Ab-1/ GM-Tg-bovg-T14731-Ab-2; GM-Tg-equg-T14731-Ab-1/ GM-Tg-equg-T14731-Ab-2
Products NameAnti-SIRT1 monoclonal antibody
Formatmab
Target NameSIRT1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-SIRT1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T14731-Ag-1Recombinant multi-species SIR1/ SIRT1/ SIR2 protein
    ORF Viral VectorpGMAD000463human SIRT1 Adenovirus plasmid
    ORF Viral VectorpGMLV000525human SIRT1 Lentivirus plasmid
    ORF Viral VectorvGMAD000463human SIRT1 Adenovirus particle
    ORF Viral VectorpGMLV000135human SIRT1 Lentivirus plasmid
    ORF Viral VectorvGMAD000579human SIRT1 Adenovirus particle
    ORF Viral VectorpGMAD000579human SIRT1 Adenovirus plasmid
    ORF Viral VectorvGMLV000135human SIRT1 Lentivirus particle
    ORF Viral VectorvGMAP000577Human SIRT1 Adenovirus particle
    ORF Viral VectorpGMAP000577Human SIRT1 Adenovirus plasmid
    ORF Viral VectorvGMLV000525human SIRT1 Lentivirus particle
    ORF Viral VectorpGMLV000090mouse Sirt1 Lentivirus plasmid
    ORF Viral VectorpGMLV000581house mouse Sirt1 Lentivirus plasmid
    ORF Viral VectorpGMLV000831house mouse Sirt1 Lentivirus plasmid
    ORF Viral VectorpGMAD000091cattle SIRT1 Adenovirus plasmid
    ORF Viral VectorpGMAD000529Norway rat Sirt1 Adenovirus plasmid
    ORF Viral VectorpGMAD000537house mouse Sirt1 Adenovirus plasmid
    ORF Viral VectorpGMAD000630house mouse Sirt1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000201Norway rat Sirt1 AAV plasmid
    ORF Viral VectorvGMLV000090mouse Sirt1 Lentivirus particle
    ORF Viral VectorvGMLV000581house mouse Sirt1 Lentivirus particle
    ORF Viral VectorvGMLV000831house mouse Sirt1 Lentivirus particle
    ORF Viral VectorvGMAD000091cattle SIRT1 Adenovirus particle
    ORF Viral VectorvGMAD000529Norway rat Sirt1 Adenovirus particle
    ORF Viral VectorvGMAD000537house mouse Sirt1 Adenovirus particle
    ORF Viral VectorvGMAD000630house mouse Sirt1 Adenovirus particle
    ORF Viral VectorvGMAAV000201Norway rat Sirt1 AAV particle


    Target information

    Target IDGM-T14731
    Target NameSIRT1
    Gene ID23411,93759,309757,695682,489012,101087610,613629,100072571
    Gene Symbol and SynonymsSIR2,Sir2a,SIR2alpha,SIR2L1,SIRT1,sirtuin-1
    Uniprot AccessionQ96EB6,A0A0G2JZ79
    Uniprot Entry NameSIR1_HUMAN,SIR1_RAT
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000096717
    Target ClassificationTumor-associated antigen (TAA)

    The target: SIRT1, gene name: SIRT1, also named as SIR2, SIR2L1, SIR2alpha. This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.