CCL2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD

It's the GeneMedi's summary page for Target/Biomarker Introduction of CCL2. The page also collects GeneMedi's different modalities and formats products for CCL2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the CCL2 target is also connected to human indications/diseases/conditions/MOA.

Target sublocation: Secreted Protein/Potential Cytokines.

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020]

Target ID	GM-T11309
Target Name	CCL2
Gene ID	6347,20296,574138
Gene Symbol and Synonyms	CCL2,GDCF-2,HC11,HSMCR30,JE,MCAF,MCP-1,MCP1,SCYA2,Sigje,SMC-CF
Uniprot Accession	P13500,P61275
Uniprot Entry Name	CCL2_HUMAN,CCL2_MACMU
Protein Sub-location	Secreted Protein/Potential Cytokines
Category	Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
Disease	Breast Cancer, Systemic lupus erythematosus (SLE), Idiopathic hypoparathyroidism, IgA glomerulonephritis, Lupus Glomerulonephritis, Nephrotic syndrome, Nephrotic syndrome with focal and segmental glomerular lesions, Overactive bladder, Proteinuria, Renal fibrosis, Schistosomiasis, Tubulo-interstitial nephropathy in systemic lupus erythematosus, Urolithiasis, Vasculitis, Autosomal Dominant Polycystic Kidney Disease, Bacterial sepsis of newborn, Chronic Kidney Disease, Congenital hydronephrosis, Congenital occlusion of ureteropelvic junction, Diabetic Nephropathy, Glomerulonephritis, Hepatic fibrosis, Hydronephrosis with renal and ureteral calculous obstruction, Hypertension, Type 2 diabetes mellitus with diabetic nephropathy, breast cancer
Gene Ensembl	ENSG00000108691
Target Classification	Checkpoint-Immuno Oncology

Pre-made CCL2-specific INN-index biosimilar (antibody&conjugates)

Anti-CCL2 therapeutic INN-index antibodies and conjugates are biosimilars expressed by mammalian cell line as a benchmark reference therapeutic antibody for drug discovery, target MOA research, cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).

Cat No.	Products Name (INN Index)	INN Name	Previous Name	Target	Format	Detail
GMP-Bios-ab-094	Pre-Made Carlumab biosimilar, Whole mAb, Anti-CCL2 Antibody: Anti-HC11/MCAF/MCP1/MCP-1/SCYA2/GDCF-2/SMC-CF/HSMCR30 therapeutic antibody	Carlumab		CCL2	Whole mAb	Detail

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Pre-made anti-CCL2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research

Pre-made anti-CCL2 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-CCL2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

Antibody Name	Species	Format	Classified by tag	Detail
Anti-CCL2 monoclonal antibody	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	mab	FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody	Detail

Recombinant multi-species CCL2/ GDCF-2/ HC11 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CCL2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

Products Name	Species	Expression Platform	Detail
CCL2 protein	Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine	Mammalian cell	Detail

Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse chemokine (C-C motif) ligand 2 (CCL2) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.

The chemokine (C-C motif) ligand 2 (CCL2) is also referred to as monocyte chemoattractant protein 1 (MCP1) and small inducible cytokine A2. CCL2 is a small cytokine that belongs to the CC chemokine family. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection.

Target	Species	Antigen Product Name	Bioactivity validation of Antigen	Antibody Product Name	Bioactivity validation of Antibodies	Detail
CCL2	Human, Cynomolgus/Rhesus macaque, rat, mouse	chemokine (C-C motif) ligand 2 (CCL2) protein	Affintiy&bioactivity validated by ELISA, cell culture validated	Anti-CCL2 monoclonal antibody	Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).	Detail

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Pre-made CCL2 viral vector in GM Promise-ORF^TM

Cat No.	Products name	NM ID	Species	Type	Detail
pGMAP000030	Human CCL2 Adenovirus plasmid	BC009716	Human	Adenovirus plasmid	Detail
vGMAP000030	Human CCL2 Adenovirus particle	BC009716	Human	Adenovirus particle	Detail
pGMLP000392	human CCL2 Lentivirus plasmid	NM_002982	Human	Lentivirus plasmid	Detail
vGMLP000392	human CCL2 Lentivirus particle	NM_002982	Human	Lentivirus particle	Detail
pGMLPm000042	mouse Ccl2 Lentivirus plasmid	NM_011333	Mouse	Lentivirus plasmid	Detail
vGMLPm000042	mouse Ccl2 Lentivirus particle	NM_011333	Mouse	Lentivirus particle	Detail
pGMLPm003496	mouse Ccl12 Lentivirus plasmid	NM_011331	Mouse	Lentivirus plasmid	Detail
vGMLPm003496	mouse Ccl12 Lentivirus particle	NM_011331	Mouse	Lentivirus particle	Detail

About Promise-ORF^TM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORF^TM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORF^TM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI

If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.