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Anti-CCL2/ GDCF-2/ HC11 functional antibody
Anti-CCL2/ GDCF-2/ HC11 functional antibody for cell culture, ELISA & in-vivo assay
Go to CCL2/CCL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T11309-Ab-1/ GM-Tg-hg-T11309-Ab-2 | Anti-Human CCL2 monoclonal antibody | Human |
| GM-Tg-rg-T11309-Ab-1/ GM-Tg-rg-T11309-Ab-2 | Anti-Rat CCL2 monoclonal antibody | Rat |
| GM-Tg-mg-T11309-Ab-1/ GM-Tg-mg-T11309-Ab-2 | Anti-Mouse CCL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T11309-Ab-1/ GM-Tg-cynog-T11309-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T11309-Ab-1/ GM-Tg-felg-T11309-Ab-2 | Anti-Feline CCL2 monoclonal antibody | Feline |
| GM-Tg-cang-T11309-Ab-1/ GM-Tg-cang-T11309-Ab-2 | Anti-Canine CCL2 monoclonal antibody | Canine |
| GM-Tg-bovg-T11309-Ab-1/ GM-Tg-bovg-T11309-Ab-2 | Anti-Bovine CCL2 monoclonal antibody | Bovine |
| GM-Tg-equg-T11309-Ab-1/ GM-Tg-equg-T11309-Ab-2 | Anti-Equine CCL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T11309-Ab-1/ GM-Tg-hg-T11309-Ab-2; GM-Tg-rg-T11309-Ab-1/ GM-Tg-rg-T11309-Ab-2; GM-Tg-mg-T11309-Ab-1/ GM-Tg-mg-T11309-Ab-2; GM-Tg-cynog-T11309-Ab-1/ GM-Tg-cynog-T11309-Ab-2; GM-Tg-felg-T11309-Ab-1/ GM-Tg-felg-T11309-Ab-2; GM-Tg-cang-T11309-Ab-1/ GM-Tg-cang-T11309-Ab-2; GM-Tg-bovg-T11309-Ab-1/ GM-Tg-bovg-T11309-Ab-2; GM-Tg-equg-T11309-Ab-1/ GM-Tg-equg-T11309-Ab-2 |
| Products Name | Anti-CCL2 monoclonal antibody |
| Format | mab |
| Target Name | CCL2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-094 | Pre-Made Carlumab biosimilar, Whole mAb, Anti-CCL2 Antibody: Anti-HC11/MCAF/MCP1/MCP-1/SCYA2/GDCF-2/SMC-CF/HSMCR30 therapeutic antibody |
| Target Antigen | GM-Tg-g-T11309-Ag-1 | Recombinant multi-species CCL2/ GDCF-2/ HC11 protein |
| Cytokine | GM-Tg-g-T11309-Ag-1 | chemokine (C-C motif) ligand 2 (CCL2) protein |
| ORF Viral Vector | pGMAP000030 | Human CCL2 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000030 | Human CCL2 Adenovirus particle |
| ORF Viral Vector | pGMLP000392 | human CCL2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000392 | human CCL2 Lentivirus particle |
| ORF Viral Vector | pGMLPm000042 | mouse Ccl2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000042 | mouse Ccl2 Lentivirus particle |
| ORF Viral Vector | pGMLPm003496 | mouse Ccl12 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003496 | mouse Ccl12 Lentivirus particle |
Target information
| Target ID | GM-T11309 |
| Target Name | CCL2 |
| Gene ID | 6347,20296,574138 |
| Gene Symbol and Synonyms | CCL2,GDCF-2,HC11,HSMCR30,JE,MCAF,MCP-1,MCP1,SCYA2,Sigje,SMC-CF |
| Uniprot Accession | P13500,P61275 |
| Uniprot Entry Name | CCL2_HUMAN,CCL2_MACMU |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Breast Cancer, Systemic lupus erythematosus (SLE), Idiopathic hypoparathyroidism, IgA glomerulonephritis, Lupus Glomerulonephritis, Nephrotic syndrome, Nephrotic syndrome with focal and segmental glomerular lesions, Overactive bladder, Proteinuria, Renal fibrosis, Schistosomiasis, Tubulo-interstitial nephropathy in systemic lupus erythematosus, Urolithiasis, Vasculitis, Autosomal Dominant Polycystic Kidney Disease, Bacterial sepsis of newborn, Chronic Kidney Disease, Congenital hydronephrosis, Congenital occlusion of ureteropelvic junction, Diabetic Nephropathy, Glomerulonephritis, Hepatic fibrosis, Hydronephrosis with renal and ureteral calculous obstruction, Hypertension, Type 2 diabetes mellitus with diabetic nephropathy, breast cancer |
| Gene Ensembl | ENSG00000108691 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: CCL2, gene name: CCL2, also named as GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF. This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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