WNT2: Target/Biomarker Introduction, products summarized (antibody/ADC/bispecific/antigen/ORF vector/VLP) and disease/indication/condition/MOA for drug discovery and IVD
It's the GeneMedi's summary page for Target/Biomarker Introduction of WNT2. The page also collects GeneMedi's different modalities and formats products for WNT2 in therapeutics/drug discovery and IVD diagnostics, which is including antibody, ADC, bispecific, antigen, ORF vector, VLP, etc. With GeneMedi's target-insight database-GM ITD database, the WNT2 target is also connected to human indications/diseases/conditions/MOA.
Target sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
Target ID | GM-SE1383 |
Target Name | WNT2 |
Gene ID | 7472,22413,114487,704991,612141,493672,493729,100056092 |
Gene Symbol and Synonyms | 2610510E18Rik,INT1L1,IRP,Mirp,Wnt,Wnt-2,WNT2,Wnt2a |
Uniprot Accession | P09544,A0M8T2,A4D7S0,Q2QLA5 |
Uniprot Entry Name | WNT2_HUMAN,WNT2_FELCA,WNT2_BOVIN,WNT2_HORSE |
Protein Sub-location | Secreted Protein/Potential Cytokines |
Category | Cytokine Target |
Disease | Cancer |
Gene Ensembl | ENSG00000105989 |
Target Classification | Tumor-associated antigen (TAA) |
Pre-made anti-WNT2 inhibitory monoclonal antibody(mab, blocking antibody inhibitor)-benchmark antibody for drug discovery and mechanism of action (MOA) research
Pre-made anti-WNT2 benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-WNT2 mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Antibody Name | Species | Format | Classified by tag | Detail |
Anti-WNT2 monoclonal antibody | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | mab | FACS/Biofunctional Antibody, Cytokine antibody | Detail |
Recombinant multi-species WNT2/ INT1L1/ IRP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine WNT2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Products Name | Species | Expression Platform | Detail |
WNT2 protein | Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine | Mammalian cell | Detail |
Cytokine Products for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces human, Cynomolgus/ Rhesus macaque, rat, mouse wingless-type MMTV integration site family member 2 (WNT2) His+Avi (Biotinylated) for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.? This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.
Target | Species | Antigen Product Name | Bioactivity validation of Antigen | Antibody Product Name | Bioactivity validation of Antibodies | Detail |
WNT2 | Human, Cynomolgus/Rhesus macaque, rat, mouse | wingless-type MMTV integration site family member 2 (WNT2) protein | Affintiy&bioactivity validated by ELISA, cell culture validated | Anti-WNT2 monoclonal antibody | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). | Detail |
Click to check more Cytokine Products
Pre-made WNT2 viral vector in GM Promise-ORFTM
Cat No. | Products name | NM ID | Species | Type | Detail |
pGMLP000598 | human WNT2 Lentivirus plasmid | NM_003391 | Human | Lentivirus plasmid | Detail |
vGMLP000598 | human WNT2 Lentivirus particle | NM_003391 | Human | Lentivirus particle | Detail |
pGMAAV000192 | house mouse Wnt2 AAV plasmid | NM_023653 | House Mouse | AAV plasmid | Detail |
pGMLPm001746 | mouse Wnt2 Lentivirus plasmid | NM_023653 | Mouse | Lentivirus plasmid | Detail |
vGMAAV000192 | house mouse Wnt2 AAV particle | NM_023653 | House Mouse | AAV particle | Detail |
vGMLPm001746 | mouse Wnt2 Lentivirus particle | NM_023653 | Mouse | Lentivirus particle | Detail |
About Promise-ORFTM:
Discover the largest collection of ORF/cDNA expression clones from different species, including human, mouse, rat, and more with GeneMedi's Promise-ORFTM. Our collection of ORFs expression clones come in verified mammalian or viral vectors lentivirus, AAV, and adenovirus) and our Promise-ORFTM viral-ready expression vectors make it easy for you to improve viral vector packaging efficiency or directly transfect mammalian cells, resulting in stronger and easier expression detection. Click to search your GOI
If you want to obtain higher quantities of plasmids (mg), please visit GM TransExcellent Plasmid DNA Rapid Preparation Service.