- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-WNT2/ INT1L1/ IRP functional antibody
Anti-WNT2/ INT1L1/ IRP functional antibody for cell culture, ELISA & in-vivo assay
Go to WNT2/WNT2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-SE1383-Ab-1/ GM-Tg-hg-SE1383-Ab-2 | Anti-Human WNT2 monoclonal antibody | Human |
| GM-Tg-rg-SE1383-Ab-1/ GM-Tg-rg-SE1383-Ab-2 | Anti-Rat WNT2 monoclonal antibody | Rat |
| GM-Tg-mg-SE1383-Ab-1/ GM-Tg-mg-SE1383-Ab-2 | Anti-Mouse WNT2 monoclonal antibody | Mouse |
| GM-Tg-cynog-SE1383-Ab-1/ GM-Tg-cynog-SE1383-Ab-2 | Anti-Cynomolgus/ Rhesus macaque WNT2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-SE1383-Ab-1/ GM-Tg-felg-SE1383-Ab-2 | Anti-Feline WNT2 monoclonal antibody | Feline |
| GM-Tg-cang-SE1383-Ab-1/ GM-Tg-cang-SE1383-Ab-2 | Anti-Canine WNT2 monoclonal antibody | Canine |
| GM-Tg-bovg-SE1383-Ab-1/ GM-Tg-bovg-SE1383-Ab-2 | Anti-Bovine WNT2 monoclonal antibody | Bovine |
| GM-Tg-equg-SE1383-Ab-1/ GM-Tg-equg-SE1383-Ab-2 | Anti-Equine WNT2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-SE1383-Ab-1/ GM-Tg-hg-SE1383-Ab-2; GM-Tg-rg-SE1383-Ab-1/ GM-Tg-rg-SE1383-Ab-2; GM-Tg-mg-SE1383-Ab-1/ GM-Tg-mg-SE1383-Ab-2; GM-Tg-cynog-SE1383-Ab-1/ GM-Tg-cynog-SE1383-Ab-2; GM-Tg-felg-SE1383-Ab-1/ GM-Tg-felg-SE1383-Ab-2; GM-Tg-cang-SE1383-Ab-1/ GM-Tg-cang-SE1383-Ab-2; GM-Tg-bovg-SE1383-Ab-1/ GM-Tg-bovg-SE1383-Ab-2; GM-Tg-equg-SE1383-Ab-1/ GM-Tg-equg-SE1383-Ab-2 |
| Products Name | Anti-WNT2 monoclonal antibody |
| Format | mab |
| Target Name | WNT2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-WNT2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-SE1383-Ag-1 | Recombinant multi-species WNT2/ INT1L1/ IRP protein |
| Cytokine | GM-Tg-g-SE1383-Ag-1 | wingless-type MMTV integration site family member 2 (WNT2) protein |
| ORF Viral Vector | pGMLP000598 | human WNT2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000598 | human WNT2 Lentivirus particle |
| ORF Viral Vector | pGMAAV000192 | house mouse Wnt2 AAV plasmid |
| ORF Viral Vector | pGMLPm001746 | mouse Wnt2 Lentivirus plasmid |
| ORF Viral Vector | vGMAAV000192 | house mouse Wnt2 AAV particle |
| ORF Viral Vector | vGMLPm001746 | mouse Wnt2 Lentivirus particle |
Target information
| Target ID | GM-SE1383 |
| Target Name | WNT2 |
| Gene ID | 7472,22413,114487,704991,612141,493672,493729,100056092 |
| Gene Symbol and Synonyms | 2610510E18Rik,INT1L1,IRP,Mirp,Wnt,Wnt-2,WNT2,Wnt2a |
| Uniprot Accession | P09544,A0M8T2,A4D7S0,Q2QLA5 |
| Uniprot Entry Name | WNT2_HUMAN,WNT2_FELCA,WNT2_BOVIN,WNT2_HORSE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000105989 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: WNT2, gene name: WNT2, also named as INT1L1, IRP. This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
