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Anti-MTDC/ MTHFD2/ NMDMC functional antibody
Anti-MTDC/ MTHFD2/ NMDMC functional antibody for cell culture, ELISA & in-vivo assay
Go to MTHFD2/MTHFD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-TA058-Ab-1/ GM-Tg-hg-TA058-Ab-2 | Anti-Human MTHFD2 monoclonal antibody | Human |
| GM-Tg-rg-TA058-Ab-1/ GM-Tg-rg-TA058-Ab-2 | Anti-Rat MTHFD2 monoclonal antibody | Rat |
| GM-Tg-mg-TA058-Ab-1/ GM-Tg-mg-TA058-Ab-2 | Anti-Mouse MTHFD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-TA058-Ab-1/ GM-Tg-cynog-TA058-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MTHFD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-TA058-Ab-1/ GM-Tg-felg-TA058-Ab-2 | Anti-Feline MTHFD2 monoclonal antibody | Feline |
| GM-Tg-cang-TA058-Ab-1/ GM-Tg-cang-TA058-Ab-2 | Anti-Canine MTHFD2 monoclonal antibody | Canine |
| GM-Tg-bovg-TA058-Ab-1/ GM-Tg-bovg-TA058-Ab-2 | Anti-Bovine MTHFD2 monoclonal antibody | Bovine |
| GM-Tg-equg-TA058-Ab-1/ GM-Tg-equg-TA058-Ab-2 | Anti-Equine MTHFD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-TA058-Ab-1/ GM-Tg-hg-TA058-Ab-2; GM-Tg-rg-TA058-Ab-1/ GM-Tg-rg-TA058-Ab-2; GM-Tg-mg-TA058-Ab-1/ GM-Tg-mg-TA058-Ab-2; GM-Tg-cynog-TA058-Ab-1/ GM-Tg-cynog-TA058-Ab-2; GM-Tg-felg-TA058-Ab-1/ GM-Tg-felg-TA058-Ab-2; GM-Tg-cang-TA058-Ab-1/ GM-Tg-cang-TA058-Ab-2; GM-Tg-bovg-TA058-Ab-1/ GM-Tg-bovg-TA058-Ab-2; GM-Tg-equg-TA058-Ab-1/ GM-Tg-equg-TA058-Ab-2 |
| Products Name | Anti-MTHFD2 monoclonal antibody |
| Format | mab |
| Target Name | MTHFD2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MTHFD2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-TA058-Ag-1 | Recombinant multi-species MTDC/ MTHFD2/ NMDMC protein |
| ORF Viral Vector | vGMLP002144 | human MTHFD2 Lentivirus particle |
| ORF Viral Vector | pGMLP002144 | human MTHFD2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001444 | mouse Mthfd2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001444 | mouse Mthfd2 Lentivirus particle |
Target information
| Target ID | GM-TA058 |
| Target Name | MTHFD2 |
| Gene ID | 10797,17768,680308,714974,483107,101083836,517539,100053990 |
| Gene Symbol and Synonyms | MTHFD2,NMDMC |
| Uniprot Accession | P13995,Q0P5C2 |
| Uniprot Entry Name | MTDC_HUMAN,MTDC_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000065911 |
| Target Classification | N/A |
The target: MTHFD2, gene name: MTHFD2, also named as NMDMC. This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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