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Anti-TYMS monoclonal antibody
Pre-made anti-TYMS monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TYMS/TYMS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T98397-Ab-1/ GM-Tg-hg-T98397-Ab-2 | Anti-Human TYMS monoclonal antibody | Human |
| GM-Tg-rg-T98397-Ab-1/ GM-Tg-rg-T98397-Ab-2 | Anti-Rat TYMS monoclonal antibody | Rat |
| GM-Tg-mg-T98397-Ab-1/ GM-Tg-mg-T98397-Ab-2 | Anti-Mouse TYMS monoclonal antibody | Mouse |
| GM-Tg-cynog-T98397-Ab-1/ GM-Tg-cynog-T98397-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TYMS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T98397-Ab-1/ GM-Tg-felg-T98397-Ab-2 | Anti-Feline TYMS monoclonal antibody | Feline |
| GM-Tg-cang-T98397-Ab-1/ GM-Tg-cang-T98397-Ab-2 | Anti-Canine TYMS monoclonal antibody | Canine |
| GM-Tg-bovg-T98397-Ab-1/ GM-Tg-bovg-T98397-Ab-2 | Anti-Bovine TYMS monoclonal antibody | Bovine |
| GM-Tg-equg-T98397-Ab-1/ GM-Tg-equg-T98397-Ab-2 | Anti-Equine TYMS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T98397-Ab-1/ GM-Tg-hg-T98397-Ab-2; GM-Tg-rg-T98397-Ab-1/ GM-Tg-rg-T98397-Ab-2; GM-Tg-mg-T98397-Ab-1/ GM-Tg-mg-T98397-Ab-2; GM-Tg-cynog-T98397-Ab-1/ GM-Tg-cynog-T98397-Ab-2; GM-Tg-felg-T98397-Ab-1/ GM-Tg-felg-T98397-Ab-2; GM-Tg-cang-T98397-Ab-1/ GM-Tg-cang-T98397-Ab-2; GM-Tg-bovg-T98397-Ab-1/ GM-Tg-bovg-T98397-Ab-2; GM-Tg-equg-T98397-Ab-1/ GM-Tg-equg-T98397-Ab-2 |
| Products Name | Anti-TYMS monoclonal antibody |
| Format | mab |
| Target Name | TYMS |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TYMS monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T98397-Ag-1 | Recombinant multi-species TYSY/ TYMS/ HST422 protein |
| ORF Viral Vector | pGMLV000416 | human TYMS Lentivirus plasmid |
| ORF Viral Vector | vGMLV000416 | human TYMS Lentivirus particle |
| ORF Viral Vector | pGMLPm001126 | mouse Tyms Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001126 | mouse Tyms Lentivirus particle |
Target information
| Target ID | GM-T98397 |
| Target Name | TYMS |
| Gene ID | 7298,22171,29261,697580,607417,101091231,507631,100060971 |
| Gene Symbol and Synonyms | DKCD,HST422,™S,TS,TYMS |
| Uniprot Accession | P04818,P45352,Q2TA32 |
| Uniprot Entry Name | TYSY_HUMAN,TYSY_RAT,TYSY_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000176890 |
| Target Classification | N/A |
The target: TYMS, gene name: TYMS, also named as HST422, ™S, TS. Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the d™P (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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