Human TYMS/HST422/TMS ORF/cDNA clone-Lentivirus particle (NM_001071)

Cat. No.: vGMLV000416

Pre-made Human TYMS/HST422/TMS Lentiviral expression plasmid for TYMS lentivirus packaging, TYMS lentivirus production, overexpression stable cell line development, cell transient transfection and gene delivery targeting T/B/NK cells, macrophages, cardiomyocytes, hepatocytes, and neurons.

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pdf MSDS
pdf Datasheet

Product information

Catalog No. Product Name lentivirus Grade lentivirus quantity
vGMLV000416 Human TYMS Lentivirus particle Pilot Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
Research Grade 1.0E+8TU
5.0E+8TU
1.0E+9TU
GMP-like Grade inquiry
GMP Grade inquiry


Product Description

Catalog ID vGMLV000416
Gene Name TYMS
Accession Number NM_001071
Gene ID 7298
Species Human
Product Type Lentivirus particle (overexpression)
Insert Length 942 bp
Gene Alias HST422,TMS,TS
Fluorescent Reporter ZsGreen
Mammalian Cell Selection Puromyocin
Fusion Tag 3xflag (C-Terminal)
Promoter CMV
Resistance Amplicin
ORF Nucleotide Sequence 正确

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antibody GM-Tg-g-T98397-Ab Anti-TYMS monoclonal antibody
    Target Antigen GM-Tg-g-T98397-Ag TYMS protein
    ORF Viral Vector pGMLV000416 Human TYMS Lentivirus plasmid
    ORF Viral Vector vGMLV000416 Human TYMS Lentivirus particle


    Target information

    Target ID GM-T98397
    Target Name TYMS
    Gene ID 7298, 22171, 697580, 29261, 101091231, 607417, 507631, 100060971
    Gene Symbol and Synonyms DKCD,HST422,TMS,TS,TYMS
    Uniprot Accession P04818
    Uniprot Entry Name TYSY_HUMAN
    Protein Sub-location Introcelluar Protein
    Category Therapeutics Target
    Disease Breast Cancer
    Gene Ensembl ENSG00000176890
    Target Classification Not Available

    Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]



    About GMVC

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    GMVC (GM Vector Core) is GeneMedi’s unique platform for QbD Viral vectors Processes development and manufacturing. In GMVC, our core expertise lies in the tailored production of viral vectors, including adeno-associated virus (AAV), lentivirus, and adenovirus. Our state-of-the-art facilities are equipped for scalable manufacturing, ensuring high-quality viral vector production to meet both research and therapeutic needs. Our expert team specializes in process development, leveraging innovative technology and extensive industry knowledge to provide clients with tailored solutions that exceed expectations. GMVC will be the ideal partner for scientists and healthcare professionals seeking reliable and efficient viral vector production services.