Anti-CXCR4/ CD184/ D2S201E monoclonal antibody

Anti-CXCR4/ CD184/ D2S201E antibody for FACS & in-vivo assay

Target products collectionGo to CXCR4/CXCR4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T96079-Ab-1/ GM-Tg-hg-T96079-Ab-2Anti-Human CXCR4 monoclonal antibodyHuman
GM-Tg-rg-T96079-Ab-1/ GM-Tg-rg-T96079-Ab-2Anti-Rat CXCR4 monoclonal antibodyRat
GM-Tg-mg-T96079-Ab-1/ GM-Tg-mg-T96079-Ab-2Anti-Mouse CXCR4 monoclonal antibodyMouse
GM-Tg-cynog-T96079-Ab-1/ GM-Tg-cynog-T96079-Ab-2Anti-Cynomolgus/ Rhesus macaque CXCR4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T96079-Ab-1/ GM-Tg-felg-T96079-Ab-2Anti-Feline CXCR4 monoclonal antibodyFeline
GM-Tg-cang-T96079-Ab-1/ GM-Tg-cang-T96079-Ab-2Anti-Canine CXCR4 monoclonal antibodyCanine
GM-Tg-bovg-T96079-Ab-1/ GM-Tg-bovg-T96079-Ab-2Anti-Bovine CXCR4 monoclonal antibodyBovine
GM-Tg-equg-T96079-Ab-1/ GM-Tg-equg-T96079-Ab-2Anti-Equine CXCR4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T96079-Ab-1/ GM-Tg-hg-T96079-Ab-2; GM-Tg-rg-T96079-Ab-1/ GM-Tg-rg-T96079-Ab-2;
GM-Tg-mg-T96079-Ab-1/ GM-Tg-mg-T96079-Ab-2; GM-Tg-cynog-T96079-Ab-1/ GM-Tg-cynog-T96079-Ab-2;
GM-Tg-felg-T96079-Ab-1/ GM-Tg-felg-T96079-Ab-2; GM-Tg-cang-T96079-Ab-1/ GM-Tg-cang-T96079-Ab-2;
GM-Tg-bovg-T96079-Ab-1/ GM-Tg-bovg-T96079-Ab-2; GM-Tg-equg-T96079-Ab-1/ GM-Tg-equg-T96079-Ab-2
Products NameAnti-CXCR4 monoclonal antibody
Formatmab
Target NameCXCR4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CXCR4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-600Pre-Made Ulocuplumab biosimilar, Whole mAb, Anti-CXCR4 Antibody: Anti-FB22/HM89/LAP3/LCR1/NPYR/WHIM/CD184/LAP-3/LESTR/NPY3R/NPYRL/WHIMS/HSY3RR/NPYY3R/WHIMS1/D2S201E therapeutic antibody
    Target AntigenProducts DevelopingMulti-species CXCR4/ CD184/ D2S201E VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T96079-Ag-1chemokine (C-X-C motif) receptor 4 (CXCR4) protein
    ORF Viral VectorvGMLV000695human CXCR4 Lentivirus particle
    ORF Viral VectorpGMLP000599human CXCR4 Lentivirus plasmid
    ORF Viral VectorpGMLP003262human CXCR4 Lentivirus plasmid
    ORF Viral VectorpGMLV000695human CXCR4 Lentivirus plasmid
    ORF Viral VectorvGMLP000599human CXCR4 Lentivirus particle
    ORF Viral VectorvGMLP003262human CXCR4 Lentivirus particle
    ORF Viral VectorpGMLV000634human CXCR4 Lentivirus plasmid
    ORF Viral VectorvGMLV000634human CXCR4 Lentivirus particle
    ORF Viral VectorpGMLV000065rat Cxcr4 Lentivirus plasmid
    ORF Viral VectorpGMLV000155mouse Cxcr4 Lentivirus plasmid
    ORF Viral VectorpGMAAV000046mouse Cxcr4 AAV plasmid
    ORF Viral VectorvGMLV000065rat Cxcr4 Lentivirus particle
    ORF Viral VectorvGMLV000155mouse Cxcr4 Lentivirus particle
    ORF Viral VectorvGMAAV000046mouse Cxcr4 AAV particle


    Target information

    Target IDGM-T96079
    Target NameCXCR4
    Gene ID7852,12767,60628,707329,119863891,493676,281736,100050974
    Gene Symbol and Synonymsb2b220Clo,CD184,Cmkar4,CXC-R4,CXCR-4,CXCR4,D2S201E,FB22,HM89,HSY3RR,LAP-3,LAP3,LCR1,LESTR,LOC119863891,NPY3R,NPYR,NPYRL,NPYY3R,PB-CKR,PBSF/SDF-1,Sdf1r,WHIM,WHIMS,WHIMS1
    Uniprot AccessionP61073,O08565,P79394,P56498,P25930
    Uniprot Entry NameCXCR4_HUMAN,CXCR4_MACMU,CXCR4_RAT,CXCR4_FELCA,CXCR4_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000121966
    Target ClassificationCheckpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA)

    The target: CXCR4, gene name: CXCR4, also named as CD184, D2S201E, FB22, HM89, HSY3RR, LAP-3, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM, WHIMS. This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.