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Anti-BAP1 monoclonal antibody
Pre-made anti-BAP1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BAP1/BAP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92628-Ab-1/ GM-Tg-hg-T92628-Ab-2 | Anti-Human BAP1 monoclonal antibody | Human |
| GM-Tg-rg-T92628-Ab-1/ GM-Tg-rg-T92628-Ab-2 | Anti-Rat BAP1 monoclonal antibody | Rat |
| GM-Tg-mg-T92628-Ab-1/ GM-Tg-mg-T92628-Ab-2 | Anti-Mouse BAP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T92628-Ab-1/ GM-Tg-cynog-T92628-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BAP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92628-Ab-1/ GM-Tg-felg-T92628-Ab-2 | Anti-Feline BAP1 monoclonal antibody | Feline |
| GM-Tg-cang-T92628-Ab-1/ GM-Tg-cang-T92628-Ab-2 | Anti-Canine BAP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T92628-Ab-1/ GM-Tg-bovg-T92628-Ab-2 | Anti-Bovine BAP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T92628-Ab-1/ GM-Tg-equg-T92628-Ab-2 | Anti-Equine BAP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92628-Ab-1/ GM-Tg-hg-T92628-Ab-2; GM-Tg-rg-T92628-Ab-1/ GM-Tg-rg-T92628-Ab-2; GM-Tg-mg-T92628-Ab-1/ GM-Tg-mg-T92628-Ab-2; GM-Tg-cynog-T92628-Ab-1/ GM-Tg-cynog-T92628-Ab-2; GM-Tg-felg-T92628-Ab-1/ GM-Tg-felg-T92628-Ab-2; GM-Tg-cang-T92628-Ab-1/ GM-Tg-cang-T92628-Ab-2; GM-Tg-bovg-T92628-Ab-1/ GM-Tg-bovg-T92628-Ab-2; GM-Tg-equg-T92628-Ab-1/ GM-Tg-equg-T92628-Ab-2 |
| Products Name | Anti-BAP1 monoclonal antibody |
| Format | mab |
| Target Name | BAP1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BAP1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T92628-Ag-1 | Recombinant multi-species BAP1/ HUCEP-13/ UCHL2 protein |
| ORF Viral Vector | pGMLPm003594 | mouse Bap1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003594 | mouse Bap1 Lentivirus particle |
Target information
| Target ID | GM-T92628 |
| Target Name | BAP1 |
| Gene ID | 8314,104416,306257,697221,484737,101092671,100124510,100051934 |
| Gene Symbol and Synonyms | 2300006C11Rik,BAP1,HUCEP-13,hucep-6,KURIS,mKIAA0272,TPDS1,UBM2,uch-x4,UCHL2,UVM2 |
| Uniprot Accession | Q92560,D3ZHS6,A2VDM8 |
| Uniprot Entry Name | BAP1_HUMAN,BAP1_RAT,BAP1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000163930 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: BAP1, gene name: BAP1, also named as HUCEP-13, UCHL2, hucep-6. This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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