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Anti-ERBB4/ Erbb-4/ ALS19 monoclonal antibody
Anti-ERBB4/ Erbb-4/ ALS19 antibody for FACS & in-vivo assay
Go to Erbb-4/ERBB4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T92057-Ab-1/ GM-Tg-hg-T92057-Ab-2 | Anti-Human Erbb-4/ERBB4 monoclonal antibody | Human |
| GM-Tg-rg-T92057-Ab-1/ GM-Tg-rg-T92057-Ab-2 | Anti-Rat Erbb-4/ERBB4 monoclonal antibody | Rat |
| GM-Tg-mg-T92057-Ab-1/ GM-Tg-mg-T92057-Ab-2 | Anti-Mouse Erbb-4/ERBB4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T92057-Ab-1/ GM-Tg-cynog-T92057-Ab-2 | Anti-Cynomolgus/ Rhesus macaque Erbb-4/ERBB4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T92057-Ab-1/ GM-Tg-felg-T92057-Ab-2 | Anti-Feline Erbb-4/ERBB4 monoclonal antibody | Feline |
| GM-Tg-cang-T92057-Ab-1/ GM-Tg-cang-T92057-Ab-2 | Anti-Canine Erbb-4/ERBB4 monoclonal antibody | Canine |
| GM-Tg-bovg-T92057-Ab-1/ GM-Tg-bovg-T92057-Ab-2 | Anti-Bovine Erbb-4/ERBB4 monoclonal antibody | Bovine |
| GM-Tg-equg-T92057-Ab-1/ GM-Tg-equg-T92057-Ab-2 | Anti-Equine Erbb-4/ERBB4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T92057-Ab-1/ GM-Tg-hg-T92057-Ab-2; GM-Tg-rg-T92057-Ab-1/ GM-Tg-rg-T92057-Ab-2; GM-Tg-mg-T92057-Ab-1/ GM-Tg-mg-T92057-Ab-2; GM-Tg-cynog-T92057-Ab-1/ GM-Tg-cynog-T92057-Ab-2; GM-Tg-felg-T92057-Ab-1/ GM-Tg-felg-T92057-Ab-2; GM-Tg-cang-T92057-Ab-1/ GM-Tg-cang-T92057-Ab-2; GM-Tg-bovg-T92057-Ab-1/ GM-Tg-bovg-T92057-Ab-2; GM-Tg-equg-T92057-Ab-1/ GM-Tg-equg-T92057-Ab-2 |
| Products Name | Anti-Erbb-4/ERBB4 monoclonal antibody |
| Format | mab |
| Target Name | Erbb-4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-Erbb-4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ERBB4/ Erbb-4/ ALS19 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T92057-Ag-1 | erb-b2 receptor tyrosine kinase 4 (ERBB4) protein |
| ORF Viral Vector | vGMLV000881 | human ERBB4 Lentivirus particle |
| ORF Viral Vector | pGMLV000881 | human ERBB4 Lentivirus plasmid |
Target information
| Target ID | GM-T92057 |
| Target Name | Erbb-4 |
| Gene ID | 2066,13869,59323,693341,488508,101100073,522419,100050182 |
| Gene Symbol and Synonyms | ALS19,c-erbB-4,ERBB4,HER4,p180erbB4 |
| Uniprot Accession | Q15303,Q62956 |
| Uniprot Entry Name | ERBB4_HUMAN,ERBB4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000178568 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: Erbb-4, gene name: ERBB4, also named as ALS19, HER4, p180erbB4. This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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