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Anti-LRP1/ LRP-1/ A2MR monoclonal antibody
Anti-LRP1/ LRP-1/ A2MR antibody for FACS & in-vivo assay
Go to LRP-1/LRP1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T91130-Ab-1/ GM-Tg-hg-T91130-Ab-2 | Anti-Human LRP-1/LRP1 monoclonal antibody | Human |
| GM-Tg-rg-T91130-Ab-1/ GM-Tg-rg-T91130-Ab-2 | Anti-Rat LRP-1/LRP1 monoclonal antibody | Rat |
| GM-Tg-mg-T91130-Ab-1/ GM-Tg-mg-T91130-Ab-2 | Anti-Mouse LRP-1/LRP1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T91130-Ab-1/ GM-Tg-cynog-T91130-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LRP-1/LRP1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T91130-Ab-1/ GM-Tg-felg-T91130-Ab-2 | Anti-Feline LRP-1/LRP1 monoclonal antibody | Feline |
| GM-Tg-cang-T91130-Ab-1/ GM-Tg-cang-T91130-Ab-2 | Anti-Canine LRP-1/LRP1 monoclonal antibody | Canine |
| GM-Tg-bovg-T91130-Ab-1/ GM-Tg-bovg-T91130-Ab-2 | Anti-Bovine LRP-1/LRP1 monoclonal antibody | Bovine |
| GM-Tg-equg-T91130-Ab-1/ GM-Tg-equg-T91130-Ab-2 | Anti-Equine LRP-1/LRP1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T91130-Ab-1/ GM-Tg-hg-T91130-Ab-2; GM-Tg-rg-T91130-Ab-1/ GM-Tg-rg-T91130-Ab-2; GM-Tg-mg-T91130-Ab-1/ GM-Tg-mg-T91130-Ab-2; GM-Tg-cynog-T91130-Ab-1/ GM-Tg-cynog-T91130-Ab-2; GM-Tg-felg-T91130-Ab-1/ GM-Tg-felg-T91130-Ab-2; GM-Tg-cang-T91130-Ab-1/ GM-Tg-cang-T91130-Ab-2; GM-Tg-bovg-T91130-Ab-1/ GM-Tg-bovg-T91130-Ab-2; GM-Tg-equg-T91130-Ab-1/ GM-Tg-equg-T91130-Ab-2 |
| Products Name | Anti-LRP-1/LRP1 monoclonal antibody |
| Format | mab |
| Target Name | LRP-1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LRP-1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LRP1/ LRP-1/ A2MR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMAP000292 | Human LRP1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000292 | Human LRP1 Adenovirus particle |
Target information
| Target ID | GM-T91130 |
| Target Name | LRP-1 |
| Gene ID | 4035,16971,299858,710965,481124,101090780,533894,100052936 |
| Gene Symbol and Synonyms | A2MR,APOER,APR,b2b1554Clo,CD91,IGFBP-3R,IGFBP3R,IGFBP3R1,KPA,LRP,LRP-1,LRP1,LRP1A,TGFBR5 |
| Uniprot Accession | Q07954,G3V928 |
| Uniprot Entry Name | LRP1_HUMAN,LRP1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000123384 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LRP-1, gene name: LRP1, also named as A2MR, APOER, APR, CD91, IGFBP-3R, IGFBP3R, IGFBP3R1, KPA, LRPA, TGFBR5, LRP1. This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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