Anti-FTH1 monoclonal antibody

Pre-made anti-FTH1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to FTH1/FTH1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T89873-Ab-1/ GM-Tg-hg-T89873-Ab-2Anti-Human FTH1 monoclonal antibodyHuman
GM-Tg-rg-T89873-Ab-1/ GM-Tg-rg-T89873-Ab-2Anti-Rat FTH1 monoclonal antibodyRat
GM-Tg-mg-T89873-Ab-1/ GM-Tg-mg-T89873-Ab-2Anti-Mouse FTH1 monoclonal antibodyMouse
GM-Tg-cynog-T89873-Ab-1/ GM-Tg-cynog-T89873-Ab-2Anti-Cynomolgus/ Rhesus macaque FTH1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T89873-Ab-1/ GM-Tg-felg-T89873-Ab-2Anti-Feline FTH1 monoclonal antibodyFeline
GM-Tg-cang-T89873-Ab-1/ GM-Tg-cang-T89873-Ab-2Anti-Canine FTH1 monoclonal antibodyCanine
GM-Tg-bovg-T89873-Ab-1/ GM-Tg-bovg-T89873-Ab-2Anti-Bovine FTH1 monoclonal antibodyBovine
GM-Tg-equg-T89873-Ab-1/ GM-Tg-equg-T89873-Ab-2Anti-Equine FTH1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T89873-Ab-1/ GM-Tg-hg-T89873-Ab-2; GM-Tg-rg-T89873-Ab-1/ GM-Tg-rg-T89873-Ab-2;
GM-Tg-mg-T89873-Ab-1/ GM-Tg-mg-T89873-Ab-2; GM-Tg-cynog-T89873-Ab-1/ GM-Tg-cynog-T89873-Ab-2;
GM-Tg-felg-T89873-Ab-1/ GM-Tg-felg-T89873-Ab-2; GM-Tg-cang-T89873-Ab-1/ GM-Tg-cang-T89873-Ab-2;
GM-Tg-bovg-T89873-Ab-1/ GM-Tg-bovg-T89873-Ab-2; GM-Tg-equg-T89873-Ab-1/ GM-Tg-equg-T89873-Ab-2
Products NameAnti-FTH1 monoclonal antibody
Formatmab
Target NameFTH1
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-FTH1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T89873-Ag-1Recombinant multi-species FRIH/ FTH1/ FHC protein
    ORF Viral VectorpGMAP000151Human FTH1 Adenovirus plasmid
    ORF Viral VectorvGMLV000308human FTH1 Lentivirus particle
    ORF Viral VectorpGMLV000308human FTH1 Lentivirus plasmid
    ORF Viral VectorvGMLV000307human FTH1 Lentivirus particle
    ORF Viral VectorpGMLV000307human FTH1 Lentivirus plasmid
    ORF Viral VectorvGMAP000151Human FTH1 Adenovirus particle
    ORF Viral VectorpGMLV000151mouse Fth1 Lentivirus plasmid
    ORF Viral VectorpGMLV000760house mouse Fth1 Lentivirus plasmid
    ORF Viral VectorvGMLV000151mouse Fth1 Lentivirus particle
    ORF Viral VectorvGMLV000760house mouse Fth1 Lentivirus particle


    Target information

    Target IDGM-T89873
    Target NameFTH1
    Gene ID2495,14319,25319,574118,403631,654516,281173,100062811
    Gene Symbol and SynonymsFHC,FTH,FTH1,FTHL6,HFE5,HFt,LOC403631,MFH,PIG15,PLIF
    Uniprot AccessionP02794,P19132,Q2MHN2,O46414,Q8MIP0
    Uniprot Entry NameFRIH_HUMAN,FRIH_RAT,FRIH_FELCA,FRIH_BOVIN,FRIH_HORSE
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000167996
    Target ClassificationN/A

    The target: FTH1, gene name: FTH1, also named as FHC, FTH, FTHL6, HFE5, PIG15, PLIF. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.