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Anti-IDO1 monoclonal antibody
Pre-made anti-IDO1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to IDO1/IDO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T89697-Ab-1/ GM-Tg-hg-T89697-Ab-2 | Anti-Human IDO1 monoclonal antibody | Human |
| GM-Tg-rg-T89697-Ab-1/ GM-Tg-rg-T89697-Ab-2 | Anti-Rat IDO1 monoclonal antibody | Rat |
| GM-Tg-mg-T89697-Ab-1/ GM-Tg-mg-T89697-Ab-2 | Anti-Mouse IDO1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T89697-Ab-1/ GM-Tg-cynog-T89697-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IDO1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T89697-Ab-1/ GM-Tg-felg-T89697-Ab-2 | Anti-Feline IDO1 monoclonal antibody | Feline |
| GM-Tg-cang-T89697-Ab-1/ GM-Tg-cang-T89697-Ab-2 | Anti-Canine IDO1 monoclonal antibody | Canine |
| GM-Tg-bovg-T89697-Ab-1/ GM-Tg-bovg-T89697-Ab-2 | Anti-Bovine IDO1 monoclonal antibody | Bovine |
| GM-Tg-equg-T89697-Ab-1/ GM-Tg-equg-T89697-Ab-2 | Anti-Equine IDO1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T89697-Ab-1/ GM-Tg-hg-T89697-Ab-2; GM-Tg-rg-T89697-Ab-1/ GM-Tg-rg-T89697-Ab-2; GM-Tg-mg-T89697-Ab-1/ GM-Tg-mg-T89697-Ab-2; GM-Tg-cynog-T89697-Ab-1/ GM-Tg-cynog-T89697-Ab-2; GM-Tg-felg-T89697-Ab-1/ GM-Tg-felg-T89697-Ab-2; GM-Tg-cang-T89697-Ab-1/ GM-Tg-cang-T89697-Ab-2; GM-Tg-bovg-T89697-Ab-1/ GM-Tg-bovg-T89697-Ab-2; GM-Tg-equg-T89697-Ab-1/ GM-Tg-equg-T89697-Ab-2 |
| Products Name | Anti-IDO1 monoclonal antibody |
| Format | mab |
| Target Name | IDO1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-IDO1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T89697-Ag-1 | Recombinant multi-species I23O1/ IDO1/ IDO protein |
| ORF Viral Vector | pGMAD000139 | human IDO1 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000300 | human IDO1 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000139 | human IDO1 Adenovirus particle |
| ORF Viral Vector | vGMLV000300 | human IDO1 Lentivirus particle |
| ORF Viral Vector | pGMAD000210 | mouse Ido1 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000453 | house mouse Ido1 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000210 | mouse Ido1 Adenovirus particle |
| ORF Viral Vector | vGMAD000453 | house mouse Ido1 Adenovirus particle |
Target information
| Target ID | GM-T89697 |
| Target Name | IDO1 |
| Gene ID | 3620,15930,66029,574370,475574,101096977,506281,106782641 |
| Gene Symbol and Synonyms | IDO,IDO-1,IDO1,INDO |
| Uniprot Accession | P14902,Q9ERD9 |
| Uniprot Entry Name | I23O1_HUMAN,I23O1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000131203 |
| Target Classification | Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA) |
The target: IDO1, gene name: IDO1, also named as IDO, IDO-1, INDO. This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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