Anti-5HT2C/ HTR2C/ 5-HT1C monoclonal antibody

Anti-5HT2C/ HTR2C/ 5-HT1C antibody for FACS & in-vivo assay

Target products collectionGo to HTR2C/HTR2C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T83813-Ab-1/ GM-Tg-hg-T83813-Ab-2Anti-Human HTR2C monoclonal antibodyHuman
GM-Tg-rg-T83813-Ab-1/ GM-Tg-rg-T83813-Ab-2Anti-Rat HTR2C monoclonal antibodyRat
GM-Tg-mg-T83813-Ab-1/ GM-Tg-mg-T83813-Ab-2Anti-Mouse HTR2C monoclonal antibodyMouse
GM-Tg-cynog-T83813-Ab-1/ GM-Tg-cynog-T83813-Ab-2Anti-Cynomolgus/ Rhesus macaque HTR2C monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T83813-Ab-1/ GM-Tg-felg-T83813-Ab-2Anti-Feline HTR2C monoclonal antibodyFeline
GM-Tg-cang-T83813-Ab-1/ GM-Tg-cang-T83813-Ab-2Anti-Canine HTR2C monoclonal antibodyCanine
GM-Tg-bovg-T83813-Ab-1/ GM-Tg-bovg-T83813-Ab-2Anti-Bovine HTR2C monoclonal antibodyBovine
GM-Tg-equg-T83813-Ab-1/ GM-Tg-equg-T83813-Ab-2Anti-Equine HTR2C monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T83813-Ab-1/ GM-Tg-hg-T83813-Ab-2; GM-Tg-rg-T83813-Ab-1/ GM-Tg-rg-T83813-Ab-2;
GM-Tg-mg-T83813-Ab-1/ GM-Tg-mg-T83813-Ab-2; GM-Tg-cynog-T83813-Ab-1/ GM-Tg-cynog-T83813-Ab-2;
GM-Tg-felg-T83813-Ab-1/ GM-Tg-felg-T83813-Ab-2; GM-Tg-cang-T83813-Ab-1/ GM-Tg-cang-T83813-Ab-2;
GM-Tg-bovg-T83813-Ab-1/ GM-Tg-bovg-T83813-Ab-2; GM-Tg-equg-T83813-Ab-1/ GM-Tg-equg-T83813-Ab-2
Products NameAnti-HTR2C monoclonal antibody
Formatmab
Target NameHTR2C
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HTR2C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species 5HT2C/ HTR2C/ 5-HT1C VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003724human HTR2C Lentivirus plasmid
    ORF Viral VectorvGMLP003724human HTR2C Lentivirus particle
    ORF Viral VectorpGMLPm005395mouse Htr2c Lentivirus plasmid
    ORF Viral VectorvGMLPm005395mouse Htr2c Lentivirus particle


    Target information

    Target IDGM-T83813
    Target NameHTR2C
    Gene ID3358,15560,25187,708141,450240,101099620,538909,100057852
    Gene Symbol and Synonyms5-HT-1C,5-HT-2C,5-HT1C,5-HT2C,5-HT2cR,5-HTR2C,5HT-1C,5HT1c,5HT2C,5HTR2C,HTR1C,HTR2C,SR1
    Uniprot AccessionP28335,P08909,Q60F97
    Uniprot Entry Name5HT2C_HUMAN,5HT2C_RAT,5HT2C_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000147246
    Target ClassificationGPCR

    The target: HTR2C, gene name: HTR2C, also named as 5-HT1C, 5-HT2C, 5-HTR2C, 5HTR2C, HTR1C. This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.