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Anti-HGF/ DFNB39/ F-TCFB functional antibody
Anti-HGF/ DFNB39/ F-TCFB functional antibody for cell culture, ELISA & in-vivo assay
Go to HGF/HGF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T83797-Ab-1/ GM-Tg-hg-T83797-Ab-2 | Anti-Human HGF monoclonal antibody | Human |
| GM-Tg-rg-T83797-Ab-1/ GM-Tg-rg-T83797-Ab-2 | Anti-Rat HGF monoclonal antibody | Rat |
| GM-Tg-mg-T83797-Ab-1/ GM-Tg-mg-T83797-Ab-2 | Anti-Mouse HGF monoclonal antibody | Mouse |
| GM-Tg-cynog-T83797-Ab-1/ GM-Tg-cynog-T83797-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HGF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T83797-Ab-1/ GM-Tg-felg-T83797-Ab-2 | Anti-Feline HGF monoclonal antibody | Feline |
| GM-Tg-cang-T83797-Ab-1/ GM-Tg-cang-T83797-Ab-2 | Anti-Canine HGF monoclonal antibody | Canine |
| GM-Tg-bovg-T83797-Ab-1/ GM-Tg-bovg-T83797-Ab-2 | Anti-Bovine HGF monoclonal antibody | Bovine |
| GM-Tg-equg-T83797-Ab-1/ GM-Tg-equg-T83797-Ab-2 | Anti-Equine HGF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T83797-Ab-1/ GM-Tg-hg-T83797-Ab-2; GM-Tg-rg-T83797-Ab-1/ GM-Tg-rg-T83797-Ab-2; GM-Tg-mg-T83797-Ab-1/ GM-Tg-mg-T83797-Ab-2; GM-Tg-cynog-T83797-Ab-1/ GM-Tg-cynog-T83797-Ab-2; GM-Tg-felg-T83797-Ab-1/ GM-Tg-felg-T83797-Ab-2; GM-Tg-cang-T83797-Ab-1/ GM-Tg-cang-T83797-Ab-2; GM-Tg-bovg-T83797-Ab-1/ GM-Tg-bovg-T83797-Ab-2; GM-Tg-equg-T83797-Ab-1/ GM-Tg-equg-T83797-Ab-2 |
| Products Name | Anti-HGF monoclonal antibody |
| Format | mab |
| Target Name | HGF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HGF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-212 | Pre-Made Ficlatuzumab biosimilar, Whole mAb, Anti-HGF Antibody: Anti-DFNB39/F-TCF/HPTA/SF therapeutic antibody |
| Biosimilar | GMP-Bios-ab-483 | Pre-Made Rilotumumab biosimilar, Whole mAb, Anti-HGF Antibody: Anti-DFNB39/F-TCF/HPTA/SF therapeutic antibody |
| Target Antigen | GM-Tg-g-T83797-Ag-1 | Recombinant multi-species HGF/ DFNB39/ F-TCFB protein |
| Cytokine | GM-Tg-g-T83797-Ag-1 | hepatocyte growth factor (HGF) protein |
| ORF Viral Vector | vGMLV000683 | human HGF Lentivirus particle |
| ORF Viral Vector | pGMLV000683 | human HGF Lentivirus plasmid |
| ORF Viral Vector | pGMLV000432 | human HGF Lentivirus plasmid |
| ORF Viral Vector | vGMLV000432 | human HGF Lentivirus particle |
| ORF Viral Vector | pGMLV000677 | Norway rat hgf Lentivirus plasmid |
| ORF Viral Vector | vGMLV000677 | Norway rat hgf Lentivirus particle |
Target information
| Target ID | GM-T83797 |
| Target Name | HGF |
| Gene ID | 3082,15234,24446,708316,403441,493705,282879,100049848 |
| Gene Symbol and Synonyms | C230052L06Rik,DFNB39,F-TCF,HGF,HGF/SF,HGFB,HPTA,NK1,NK2,SF,SF/HGF |
| Uniprot Accession | P14210,P17945,Q867B7,Q9BH09,Q76BS1 |
| Uniprot Entry Name | HGF_HUMAN,HGF_RAT,HGF_FELCA,HGF_CANLF,HGF_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Liver Cancer, breast cancer |
| Gene Ensembl | ENSG00000019991 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: HGF, gene name: HGF, also named as DFNB39, F-TCFB, HPTA, SF, HGF. This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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